Materials Science Forum Vol. 967

Abstract: This study aims to apply cox regression analysis to predict the patient's survival to dengue disease occurring in Palopo. This study uses clinical data, namely the results of laboratory tests to determine the effect on the patient's healing period. Laboratory test results used are platelets and hematocrit. By using the MPLE method to obtain parameter estimation in the cox regression model, it is known that platelets have a stronger effect for patient resistance on DHF than hematocrit. This is based on the p-value obtained from the analysis less than alpha (0.05), which is equal to 0.0433. Patients who had an average platelet below normal when experiencing DHF are longer in their recovery period. In addition, patients with DHF ≤ 2 days, the probability to survive and recover was 90%.

Abstract: The ethanolic and ethyl acetate extracts of Piper nigrum L and Coffea canephora were evaluated for their wound healing activity in rats. Wound healing activity was studied using excision wound models in rats following topical application. Animals were divided into eight groups with three in each group. Ten Percent w/v extract of each plant was prepared in gel CMC-Na for topical application. Piper nigrum L possesses better wound healing activity than Coffea canephora.

Abstract: Dengue fever has become a major public health problem in several countries. This paper aims to review and compare a number of temporal modeling approaches that have been proposed for predicting or forecasting the occurrence of dengue fever. This review also examines influential covariates considered in these studies. A comprehensive literature search was undertaken in September 2018, using Medline (via Ebscohost), ProQuest, Scopus, and Web of Science electronic databases. The search was confined to articles in English, published in refereed journals between January 2000 and September 2018. The most popular approach to temporal modeling of dengue was found to be an autoregressive integrated moving average (ARIMA) model. A limited number of studies applied Bayesian hierarchical dynamic generalized linear models. Climatic variables were most commonly associated with dengue incidence for temporal modeling.

Abstract: Treatment for cancer disease by using traditional plant has been used since the ancient era. many plants have the potential to treat cancer, one of them is β-sitosterol. for over a decade, β-sitosterol has many functions in the human body such as treatment for the cancer patient or cholesterol treatment. for this reason, the aims of these studies were to get the best solvent system to the gain β-sitosterol compound from the bark of kelor. Extraction section showed the best solvent system is hexane: ethyl acetate by increasing polarity index and from the pharmacognostic test, hexane extract has a positive result for alkaloid and steroid but not for flavonoid test. The result of the partition of extract hexane founded that there were 4 (A-D) fractions but only C fraction has crystal yellow. Base on the IR fragment, fraction C of the bark of kelor, (Moringa oleifera Limn) has similarity with the β-sitosterol compound.

Abstract: A study out to investigate the phytochemical screening and antimicrobial activity of Sonneratia caseolaris fruit, a mangrove plant from Maros Regency, South Sulawesi, Indonesia. The Sonneratia caseolaris extract was prepared by two different solvent: ethyl acetate and ethanol 70%. We tested the extract of Sonneratia caseolaris for antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH). The phytochemicals were extracted separately with ethyl acetate and ethanol 70% by maceration. The evaluation of antibacterial activity for different solvent with different concentration of Sonneratia caseolaris fruit was measurements of inhibitory power are measured by measuring the diameter of the clear zone formed. In phytochemical test Sonneratia caseolaris fruits extracted by ethyl acetate solvent confirmed the presence of flavanoids, saponin, tannin and phenolic and extracted by ethanol 70% solvent confirmed the presence of alkaloid, saponin and phenolic. The antioxidant activity as indicated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity of the Sonneratia caseolaris fruits extract from the species was found to be quite appreciable. The antioxidant scavenging activity of Sonneratia caseolaris fruit extract by ethyl acetate solvent was 0.38% and by ethanol solvent was 0.08%. Antimicrobial activity of Sonnerati caseolaris fruits ethyl acetate extract obtained significant was from P<0.05 of Escherechia.coli and Candida albicans but not significant of Staphylococcus aureus. The Sonneratia caseolaris extracted by ethanol 70% solvents was highly promising among Escherichia coli, Staphylococcus aureus and Candida albicans with level of significance was from P <0.05. The study suggests Sonneratia caseolaris fruits as a potential source of bioactive compounds with stable antioxidative and antimicrobial properties and can be used as natural antimicrobial/antioxidative agents in clinical, pharmaceutical and food processing industries.

Abstract: This study aims to examine the activity of the antioxidant activity of ethanol extract of lontar fruit peel (Borassus flabellifer l.) and ginger bud (Etlingera elatior (Jack.) R.M. SM) by using the ferric reducing antioxidant power method. Extraction was carried out by maceration method using 70% ethanol. The extracts were analyzed quantitatively with the addition of FRAP reagents measured by UV-Vis spectrophotometer analyzed at a wavelength of 752.29 nm in the ginger bud fruit peel and 727.05 nm for palm fruit skin using a quartetine as a comparison. Based on data analysis, the average value of the three antioxidant activity of the replication was 2.482 mg QE / g Extract on the skin of ginger bud fruit and 99.846 mgQE / g extract for lontar fruit skin. The conclusion shows that both the ginger bud fruit skin and lontar fruit skin have antioxidant activity.

Abstract: Plant Rumput Mutiara (Hedyotis corymbosa (L.) Lamk) is one of the family species of Rubiaceae which is used as a traditional medicine that is effective in healing boils, acne, anti-inflammatory, and anticancer. Research methods include maceration, fractionation, purification, class test and bioactivity test with Kirby-Bauer diffusion method using E.coli bacteria. The results of this research are pure isolates with white crystal needle shape with melting point 137-138°C. Pure isolates were analyzed using FTIR, and by the IR spectrum which showed the absorption band at wave numbers 3435.22 cm-1 indicated the presence of –OH, CH₃ and-CH₂- aliphatic groups (2956.87 cm-1; 2935.66 cm-1; 2893.22 cm-1; and 2866.22 cm-1), C = C (1641.42 cm^-1), -CH₃ and-CH₂- bending (1462.04 cm^-1 and 1377.17 cm^{- 1}), CO (1056.99 cm^-1), and = CH (964.41 cm^-1). Based on the result, it showed that the isolate was steroid group which has low antibacterial activity againts E.coli with inhibition power of 10 mm.

Abstract: Usnic acid is chemical compound commonly found in lichen. These derivatives compounds both from the synthesis and from the isolation of various lichens have been studied as antibacterial, antifungal, antiparasitic, antiviral, and anticancer. Usnat acid derivative with not hydroxyl group on carbon C-3 was isolated from lichen usnea sp. taken from the Sinjaiselatan described in this paper. Its bioactivity against Arthemia Salina Leach. LC₅₀ value of 19.49 μg/mL.

Abstract: This study aims to determine effect of boiled water parasite kapok (Dendrophthoe pentandra) leaves on the total cholesterol level and histopathology of hepar of hypercholesterolemic mice (mus musculus). This study used 20 ICR male mice divided into 4 treatment groups namely normal mice group, hypercholesterolemic mice group, mice group with boiled water kapok parasite at a dose of 400 mg/kg BW, and 800 mg/kg BW, respectivelly. The animal group was given boiled water kapok parasite after standard feeding and cholesterol feed for 2 weeks. The parameters observed in this study were total cholesterol levels, the amount of fat granules in the liver tissue of mice which were observed in the form of liver-preserved preparations made by paraffin method. The results showed that the administration of parasitic kapok (Dendrophthoe pentandra) at a dose of 400 mg/kg BW and 800 mg/kg BW had an effect on decreasing the total cholesterol level of mice and the histopathology of hepar of showed improvement after the therapy.