Paper Titles
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Inclusion Complex Formation of Water- Soluble Drug, Captopril, and Peracetylated-β-Cyclodextrin in Supercritical CO2 for Controlled Release Applications
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Hydrophobically Modified Amphiphilic Cylodextrins as Novel Carriers for Controlled Delivery of Water-Soluble Drugs
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Fabrication of Bio-Composite Drug Delivery System Using Rapid Prototyping Technology
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Supercritical Carbon Dioxide Assisted Impregnation of Molsidomine into Poly(DL-Lactide-co-Glycolide) for Sustained Release Applications
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Release Profile of a Model Protein Drug Depending on the Stability of Microspheres Based on Polyelectrolyte Complex
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All-Trans Retinoic Acid (atRA) Release from atRA-Loaded Folate-Poly(Ethylene Glycol)/Polyethylenimine Nanoparticles for Folate-Mediated Tumor Targeting
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The Double-Layered Microsphere: Encapsulation of Water-Soluble Protein with PLGA
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Controlled Angiogenic Factor Release from Alginate Gels
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Supercritical Carbon Dioxide Assisted Impregnation of Molsidomine into Poly(DL-Lactide-co-Glycolide) for Sustained Release Applications

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Abstract:

Supercritical carbon dioxide (scCO2) was used as a processing medium for the fabrication of drug encapsulated poly(DL-lactide-co-glycolide) (PLGA) monoliths for their potential application in the controlled release of water soluble drugs. Exposure of PLGA to scCO2 leads to effective plasticization and liquefaction due to the high solubility and interaction of the scCO2 in the copolymer. By exploiting this property, it was demonstrated that prolonged release formulations of molsidomine, a peripheral nitrovasodilator used to treat angina pectoris, can be prepared by chemical solvent-free, scCO2 assisted drug impregnation method. The in-vitro dissolution studies revealed that the release rates of drug from the porous polymer monoliths containing different amount of the drug samples were significantly retarded due to encapsulation of molsidomine into the PLGA matrix.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

501-504

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.501

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Online since:

July 2007

Authors:

Hullathy Subban Ganapathy, Min Hee Woo, Seong Soo Hong, Kwon Taek Lim

Keywords:

Impregnation, Molsidomine, Nitric Oxide Donor, Poly-DL-Lactide-co-Glycolide), Supercritical Carbon Dioxide

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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