Novel Long Peptide Antigens Containing MHC Class I and Class II Binding Sequences Designed from Plasmodium falciparum Enolase

Hiroyuki Oku; Yu Hashimoto; Takashi Matsukawa; Kazuo Shinozuka; Yuko Oku

doi:10.4028/www.scientific.net/AEF.38.63

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HomeAdvanced Engineering ForumAdvanced Engineering Forum Vol. 38Novel Long Peptide Antigens Containing MHC Class I...

Novel Long Peptide Antigens Containing MHC Class I and Class II Binding Sequences Designed from Plasmodium falciparum Enolase

Abstract:

Malaria caused by Plasmodium falciparum continues to be a major public health problem especially in tropical and sub-tropical regions of the world. Considering the growing resistance of parasites to anti-malarial drugs and of vector mosquitoes to insecticides, there is no doubt that the effective vaccine is the most awaiting tool to reduce the risk of malaria. Our synthetic studies have shown that a loop region (AD22 = ²⁵⁶ASEFYNSENKTYDLDFKTPNND²⁷⁷) of Plsmodium falciparum enolase has antigenic reactivity against patients’ sera and AD22 can produce inhibitory antibodies against in vitro parasite growth. In this paper, we will briefly present our ongoing research of malaria vaccine development and related model studies.

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Periodical:

Advanced Engineering Forum (Volume 38)

Pages:

63-68

DOI:

https://doi.org/10.4028/www.scientific.net/AEF.38.63

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Online since:

November 2020

Authors:

Hiroyuki Oku*, Yu Hashimoto, Takashi Matsukawa, Kazuo Shinozuka, Yuko Oku

Keywords:

Antigen, Circular Dichroism, Enolase, Malaria, Peptide, Plasmodium falciparum

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