Synthesis of Peptide Lipid (N+C5Gly2C16)

Xiao Jing Zhao; Li Ying Zhang; Li Ming Jim; Sheng Di Fan

doi:10.4028/www.scientific.net/AMM.404.118

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 404Synthesis of Peptide Lipid (N+C5Gly2C16)

Synthesis of Peptide Lipid (N⁺C₅Gly2C₁₆)

Abstract:

In the current paper, improvements were made to the synthesis of the peptide lipid N⁺C₅Gly2C₁₆ by recrystallization, which eliminated to need to use column chromatography for product purification in each step of the reaction. A simpler and more efficient synthesis process was obtained and every step of the reaction was improved. In particular steps 2 and 3 became closely associated, with the product of step 2 taken as the reactant of step 3 without purification to boost synthesis efficiency. A total synthesis ratio of 23% N⁺C₅Gly2C₁₆ was achieved from the synthesis.

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Periodical:

Applied Mechanics and Materials (Volume 404)

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118-121

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.404.118

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Online since:

September 2013

Authors:

Xiao Jing Zhao, Li Ying Zhang, Li Ming Jim, Sheng Di Fan

Keywords:

Improvement, Peptide Lipids, Recrystallization, Synthesis

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