Design of the Vitreous Bio-Micro-Channel Fabricating Device in Microfluidic System

Abstract:

In order to improve the structure, section shape and inner flow performance of micro-channel in Micro-fluidic system, a novel fabricating process of bio-micro-channel (BMC) is proposed based on the softening and forming property of glass material. By the manipulation of heating, pulling and blowing, a bio-micro-channel is made from glass capillary with specific functional units. A vitreous bio-micro-channel fabricating device (VBMCFD) is presented with working models of uniaxial and biaxial tension. Using common borosilicate glass capillary as experimental material, the affecting parameters of micro channel inner diameter, outer diameter, thickness and functional unit key parameter are tested, such as heating voltage, heating time, pulling velocity, pulling displacement and inner pressure. The bio-micro-channel is fabricated with micron scale inner diameter, about 5μm, and spherical functional unit. The experimental results show that the prototype of VBMCFD is characterized by reliable process, simple structure, low cost, etc. The vitreous bio-micro-channel is fabricated with circular-cross-section straight channels and uniform functional units, which are the key characters of biologic micro-channel.

• Periodical: Applied Mechanics and Materials (Volumes 635-637)
• Pages: 1308-1314
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.635-637.1308
• Online since: September 2014
• Authors: Gui Zhong Tian*, Wei Long Cao, Hong Gen Zhou
• Keywords: Bio-Micro-Channel (BMC), Circular-Cross-Section Straight Channel, Experiment, Functional Unit, Glass Forming, Glass Softening, Micro-Fluidic System, Prototype

References

[1] Mei Yang, Li Zhu, Liya. Hou, et al. Design and experiment of vitreous combined micro-nozzles used in digital micro-injection[J]. Optics and Precision Engineering. 2012, 20(7): 1580-1586. (in Chinese).

DOI: 10.3788/ope.20122007.1580

[2] H. Inami, K. Tsuge, M. Matsuzawa, et al. Semi-automated bacterial spore detection system with micro-fluidic chips for aerosol collection, spore treatment and ICAN DNA detection[J]. Biosensors and Bioelectronics, 2009 (24): 3299- 3305.

DOI: 10.1016/j.bios.2009.04.025

[3] D.M. Koller, N. Galler, H. Ditlbacher, et al. Direct fabrication of micro-nano fluidic channels by electron beam lithography [J]. Microelectronic Engineering, 2009 (86): 1314-1316.

DOI: 10.1016/j.mee.2008.11.025

[4] U.A. Hasran, S.K. Kanarudin, W.R.W. Daud, et al. A simple thermal oxidation technique and KOH wet etching process for fuel cell flow field fabrication [J]. International Journal of Hydrogen Energy, 2011, (36): 5136-5142.

DOI: 10.1016/j.ijhydene.2011.01.043

[5] E. Vazquez, C.A. Rodriguez, A. Elias-Zuniga, et al. An experimental analysis of process parameters to manufacture metallic micro-channels by micro-milling [J]. International Journal of Advanced Manufacture Technology, 2010(51): 945- 955.

DOI: 10.1007/s00170-010-2685-4

[6] D. SAMIRA, C. THOMAS, P. JON. Ultrafast laser machining of tapered micro-channels in glass and PDMS [J]. Optics and Lasers in Engineering, 2012, 50: 210-214.

DOI: 10.1016/j.optlaseng.2011.09.003

[7] Yong He, Jianzhong Fu, Zichen. Chen. Study on polymer flow profile in micro hot embossing [J]. Optics and Precision Engineering. 2008, 16(2): 270-278. (in Chinese).

[8] Jingmin. Li. Research on the theory and fabrication of thermoplastic microfluidic device with three-dimensional microstructures [D]. Dalian: Dalian University of Technology, 2010. (in Chinese).

[9] Xiaole Zhang, Liya Hou, Weiyi Zhang. Design and experiment of hot rheologic deformation puller for fabricating vitreous three-way micro-channel[J]. Optics and Precision Engineering. 2008, 16(9): 1706-1711. (in Chinese).

[10] X.J. Li, X.D. Wang, J. Jin, et al. Fabrication of micro-nano fluidic system combining hybrid mask-mould lithography with thermal bonding [J]. Microelectronic Engineering, 2010 (87): 722-725.

DOI: 10.1016/j.mee.2009.12.024

[11] Zongbo Zhang, Yi Luo, Xiaodong Wang, et al．A low temperature ultrasonic bonding method for PMMA microfluidic chips [J]．Microsyst Technol, 2010, 16: 533-541.

DOI: 10.1007/s00542-010-1027-7

[12] Guizhong Tian, Honggen Zhou, Bincheng Li, et al. Vitreous bio-micro- channel and its fabricating process [P]. Chinese patent: 201310070707. 5, 2013-03-06. (in Chinese).

[13] A. EUGEN. Glasses as engineering materials: A review [J]. Materials and Design. 2011, 32: 1717- 1732.

[14] Chengyu Wang, Min Chen, Jianhua Chen. Production process of glass [M]. Beijing: Chemical Industry Press, 2006. 6. (in Chinese).