A Novel Tapered Optical Fiber-Based F₀F₁-ATPase Nanobiosensor

Abstract:

In this paper, a novel high sensitive nanobiosensor based on the combination of F₀F₁-ATPase molecular motor and Φ100nm tapered optical fiber is described, which as we known has never been reported before. Since the tapered optical fiber tip is well matched with the F₀F₁-ATPase complex in size, a superb sensitivity is theoretically expected. Experimental results show that this nanobiosensor’s sensitivity is about 3.5 times higher than the result of the experiment conducted on a F₀F₁-ATPase modified ordinary Φ50μm multimode fiber biosensor. The detecting time could be decreased correspondingly. Therefore a cheap, high sensitivity ,fast response, single molecule detection of biomolecules such as epidemic viruses would be achievable using this tapered optical fiber-based F₀F₁-ATPase nanobiosensor.

• Periodical: Applied Mechanics and Materials (Volumes 687-691)
• Pages: 3403-3406
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.687-691.3403
• Online since: November 2014
• Authors: Guan Jun Wang, Zhi Bin Wang
• Keywords: F₀F₁-ATPase, Nanobiosensor, Submicron Optical Fiber

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