Experimental Identification of Heating Process from Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Equipment

Article Preview

Abstract:

Peritoneal Carcinomatosis (PC) carries a worse prognosis than other sites of systemic metastases. The combination of complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) is on the verge of becoming the gold-standard treatment of PC, when feasible. In order to develop a HIPEC equipment, with complex inflow distribution system having multiple nozzles and a multipoint temperature measurement system, model based techniques will be used by the authors in order to design heating and flow controllers. Thus a functional model is needed for the concerned process such that the simulated model and the behavior of the real system coincide. This paper presents the experimental identification of the heater used on each of the flow channels that result in a transfer function model for the heating process. Also the model for the temperature sensor is obtained

You might also be interested in these eBooks

Info:

Periodical:

Pages:

626-630

Citation:

Online since:

July 2015

Export:

Price:

Permissions CCC:

Permissions PLS:

Сopyright:

© 2015 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

[1] D.Z. Chu, N.P. Lang, C. Thompson, et al. Peritoneal carcinomatosis in nongyneco- logic malignancy. A prospective study of prognostic factors, Cancer 63 (1989) 364–7.

Google Scholar

[2] B. Sadeghi, C. Arvieux, O. Glehen, et al. Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study, Cancer 88 (2000) 358–63.

DOI: 10.1002/(sici)1097-0142(20000115)88:2<358::aid-cncr16>3.0.co;2-o

Google Scholar

[3] D.G. Jayne, S. Fook, C. Loi, et al. Peritoneal carcinomatosis from colorectal cancer, Br J Surg 89 (2002) 1545–50.

DOI: 10.1046/j.1365-2168.2002.02274.x

Google Scholar

[4] J. Franko, Q. Hhi, C. Goldman, et al. Treatment of colorectal peritoneal carcinoma-tosis with systemic chemotherapy: a pooled analysis of NCCTG's phase III trials N9741 and N9841, J Clin Oncol 29 (2011) [abstract: 3571].

DOI: 10.1200/jco.2011.29.15_suppl.3571

Google Scholar

[5] L. Saltz, S. Clarke, E. Diaz-Rubio, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study, J Clin Oncol 26 (2008) 1013–9.

DOI: 10.1200/jco.2007.14.9930

Google Scholar

[6] A. Macrì, New approach to peritoneal surface malignancies, World J Gastrointest Onco, 2(1) (2010) 9–11.

Google Scholar

[7] T. Jäger, A. Dinnewitzer, C. Augschöll, C. Rabl, et. al. Infrared thermography monitoring in closed hyperthermic intraperitoneal chemotherapy: A novel technique to maintain therapeutic intraperitoneal temperature distribution, European Journal of Surgical Oncology (EJSO) 40(11) (2014).

DOI: 10.1016/j.ejso.2014.08.048

Google Scholar

[8] K.J. Åström, B. Wittenmark, Computer Controlled Systems: Theory and Design. Third edition, Prentice Hall, Englewood Cliffs, (1996).

Google Scholar

[9] V. Muresan, Industrial processes control, UTPress Publisher, Cluj-Napoca, (2011).

Google Scholar

[10] K. Ogata, Modern control engineering. Fifth eiditon, Prentice Hall, New Jersey, (2009).

Google Scholar