A ZnS-Nanoparticle-Label-Based Electrochemical Codeine Sensor

Wei Xiong; Su Fang Wu; Fu Sheng Liao; Nian Hong; Hao Fan; Guo Bing Wei

doi:10.4028/www.scientific.net/AMM.872.173

Paper Titles

Synthesis of MoS₂/Graphene Hybrid for Electrochemical Detection and Catalytic Reduction of 4-Nitrophenol
p.149

Comparison of Surfactant Performance Using D-LIMONENE According to EO(Ethylene Oxide) Mole Number for Cleaning the Fish Cake Production Process
p.155

Fabrication of Sulfonated Bamboo Charcoal-Chitosan (sBC-CS) Hybrid and its Applications for Reinforcement of Styrene-Butadiene Rubber
p.160

Study on the Preparation and Characterization of Carboxyl Terminated Poly(L-Lactic Acid) (PLLA) Prepolymers
p.165

A ZnS-Nanoparticle-Label-Based Electrochemical Codeine Sensor
p.173

Copper Doping TiO₂ Nanotube Arrays Loaded with Hydrophilic and Hydrophobic Drugs and its Release
p.178

Application of Swirl Brake in Pipeline Compressor System
p.185

Effects of Tunable Angle for Vortex Generators on Aerodynamic Performances of Airfoils
p.192

Parameters Determination of Mooney-Rivlin Model for Rubber Material of Mechanical Elastic Wheel
p.198

HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 872A ZnS-Nanoparticle-Label-Based Electrochemical...

A ZnS-Nanoparticle-Label-Based Electrochemical Codeine Sensor

Abstract:

Codeine (3-methylmorphine) is an opiate that is widely used to treat mild or moderate pain and cough suppression. It is the second predominant alkaloid in opium with a mild sedative effect. In the present study, we describe an electrochemical sensor for codeine detection by using the DNA aptamers against codeine. In the sensing protocol, a dually-labeled DNA aptamer probe was designed to be labeled at one end with HS, and at its another end with dabcyl as an electrochemical tag to produce electrochemical signal via recognization occurrence. One special electrochemical marker was prepared by modifying ZnS nanoparticle with-cyclodextrins (ab. ZnS-CDs), which employed as electrochemical signal provider and would conjunct with the codeine probe modified electrode through the host–guest recognition of CDs to dabcyl. With codeine adding, aptamer folding allows the ZnS-CDs into soultion that caused an increase of current signal. This sensor has the ability to detect 37pM codeine. Our study demonstrates that the biosensor has good specificity and stability. It can be used to detect codeine.

You might also be interested in these eBooks

Applied Engineering, Materials and Mechanics

View Preview

Info:

Periodical:

Applied Mechanics and Materials (Volume 872)

Pages:

173-177

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.872.173

Citation:

Cite this paper

Online since:

October 2017

Authors:

Wei Xiong, Su Fang Wu, Fu Sheng Liao, Nian Hong, Hao Fan, Guo Bing Wei*

Keywords:

Aptamer, CdS Nanoparticles, Codeine, Electrochemical Sensor

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] M. A. Zayed, M. F. El-shahat, S. M. Abdullah, The use of IR, magnetism, reflectance, and mass spectra together with thermal analyses in structure investigation of codeine phosphate complexes of d-block elements, Spectrochim. Acta A, 61 (2005).

DOI: 10.1016/j.saa.2004.07.027

Google Scholar

[2] D. G. Williams, A. Patel, R. F. Howard, Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability, Br. J. Anaesth. 89 (2002) 839-845.

DOI: 10.1093/bja/aef284

Google Scholar

[3] T. T. Duong, D. H. Vu, Simultaneous Determination of Paracetamol and Codeine Phosphate in Combined Tablets by First-Order Derivative and Ratio Spectra First-Order Derivative UV Spectrophotometry, Asian J. Res. Chem. 2 (2009) 143-150.

Google Scholar

[4] L. A. Broussard, L. C. Presley, T. Pittman, R. Clouette, G. H. Wimbish, Simultaneous identification and quantitation of codeine, morphine, hydrocodone, and hydromorphone in urine as trimethylsilyl and oxime derivatives by gas chromatography-mass spectrometry. Clin. Chem. 43 (1997).

DOI: 10.1093/clinchem/43.6.1029

Google Scholar

[5] A. Alnajjar, J. A. Butcher, B. McCord, Determination of multiple drugs of abuse in human urine using capillaryelectrophoresis with fluorescence detection, Electrophor. 25 (2004) 1592-1598.

DOI: 10.1002/elps.200305847

Google Scholar

[6] Z. R. Chen, F. Bochner, A. Somogyi, Simultaneous determination of codeine, norcodeine and morphine in biological fluids by high-performance liquid chromatography with fluorescence detection, J. Chromatogr. 491 (1989) 367-373.

DOI: 10.1016/s0378-4347(00)82854-6

Google Scholar

[7] A. E. Radi, L. A. Sanchez, E. Baldrich and C. K. O'Sullivan, Reusable impedimetric aptasensor, Anal. Chem. 77 (2005) 6320-6326.

DOI: 10.1021/ac0505775

Google Scholar

[8] A. Gadelle, J. Defaye, Selective Halogenation at Primary Positions of Cyclomaltooligosaccharides and a Synthesis of Per-3, 6-anhydro Cyclomaltooligosaccharides, Angew. Chem. Int. Ed. English 30 (1991) 78-83.

DOI: 10.1002/anie.199100781

Google Scholar