The Mechanical Properties of Mimic Skin

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This paper focuses on the characterized of the mechanical properties and hyper elastic behavior of lab made skin. Bovine Serum Albumin (BSA) combined with gelatin as a base. BSA is a plasma lead concentrations or heparin plasma which is separated from blood sample and it is not associated with significant changes in iron or hemoglobin concentrations. In general, the gelatin is widely used as the best material for skin substitution since it exhibits the characteristic of human skin. However, the lab made skin layer was made of non-halal type gelatin (Type B). The methodology process started by adding the BSA and using the type A gelatin to carry out the mechanical properties and hy-per elastic behavior of halal lab made skin layer. A uniaxial tensile test standard that being used in this study is ASTM D412. The raw data (Load-Extension) from computational was plotted on graph stress-strain. The numerical approach such as Mooney-Rivlin model and Yeoh’s model were selected to analyze a stress-stretch of composition gelatin and BSA. From the results Mooney-Rivlin model, the con-stant, C1 is in the range of (0.0187-0.0658) MPa and C2 is in the range of (0.0628-0.0737) MPa. Meanwhile the constant, CP for Yeoh model is in the range of (0.0748-0.0861) MPa. As a conclusion, the composition of gelatin and Bovine Serum Albumin is a best combina-tion as it increases the strength of the lab made skin layer. Therefore, the most suitable composition is 10 wt.% of gelatin and Bovine Serum Albumin.

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73-80

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June 2020

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© 2020 Trans Tech Publications Ltd. All Rights Reserved

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[1] A. T. El-sera, I. T. El-sera, and M. Elmasry, Skin regeneration in three dimensions , current status , challenges and opportunities,, vol. 96, no. March, p.26–29, (2017).

DOI: 10.1016/j.diff.2017.06.002

Google Scholar

[2] N. F. A. Manan and J. Mahmud, The effect of skin orientation on biomechanical,, J. Mech. Eng., vol. 12, no. 1, p.67–81, (2015).

Google Scholar

[3] Y. Tu et al., Preparation and characterization of thermosensitive artificial skin with a Sandwich structure,, Mater. Lett., vol. 147, p.4–7, (2015).

Google Scholar

[4] M. Nachman and S. E. Franklin, Artificial Skin Model simulating dry and moist in vivo human skin friction and deformation behaviour,, Tribol. Int., vol. 97, p.431–439, (2016).

DOI: 10.1016/j.triboint.2016.01.043

Google Scholar

[5] T. Agarwal et al., Gelatin/Carboxymethyl chitosan based scaffolds for dermal tissue engineering applications,, Int. J. Biol. Macromol., vol. 93, p.1499–1506, (2016).

Google Scholar

[6] F. Gottrup, M. Agren, and T. Karlsmark, 24 Wound Healing,, (2000).

Google Scholar

[7] D. Hellio and M. Djabourov, Chemically and Physically Cross-linked Gelatin Gels.,.

Google Scholar

[8] F. Fathi, J. Ezzati Nazhad Dolatanbadi, M.-R. Rashidi, and Y. Omidi, Kinetic studies of bovine serum albumin interaction with PG and TBHQ using surface plasmon resonance,, Int. J. Biol. Macromol., vol. 91, p.1045–1050, (2016).

DOI: 10.1016/j.ijbiomac.2016.06.054

Google Scholar

[9] J. Y. Kim, S. B. Ryu, and K. D. Park, Journal of Industrial and Engineering Chemistry Preparation and characterization of dual-crosslinked gelatin hydrogel via Dopa-Fe 3 + complexation and fenton reaction,, J. Ind. Eng. Chem., p.1–8, (2017).

DOI: 10.1016/j.jiec.2017.09.014

Google Scholar

[10] M. Singh, K. Nuutila, K. C. Collins, and A. Huang, ScienceDirect Evolution of skin grafting for treatment of burns : Reverdin pinch grafting to Tanner mesh grafting and beyond,, Burns, vol. 43, no. 6, p.1149–1154, (2017).

DOI: 10.1016/j.burns.2017.01.015

Google Scholar

[11] G. Salgado, Y. Z. Ng, L. F. Koh, C. S. M. Goh, and J. E. Common, Human reconstructed skin xenografts on mice to model skin physiology,, Differentiation, vol. 98, no. September, p.14–24, (2017).

DOI: 10.1016/j.diff.2017.09.004

Google Scholar

[12] B. Li, V. Rama, L. Preethi, and M. S. H. Fatt, Predicting failure in rubber membranes : An experimental- numerical approach,, vol. 90, no. January, p.404–424, (2018).

DOI: 10.1016/j.engfailanal.2018.04.003

Google Scholar

[13] S. Ding and B. Bhushan, Journal of Colloid and Interface Science Tactile perception of skin and skin cream by friction induced vibrations,, J. Colloid Interface Sci., vol. 481, p.131–143, (2016).

DOI: 10.1016/j.jcis.2016.07.034

Google Scholar

[14] N. Kumaraswamy, H. Khatam, G. P. Reece, and M. C. Fingeret, Journal of the Mechanical Behavior of Biomedical Materials Mechanical response of human female breast skin under uniaxial stretching,, J. Mech. Behav. Biomed. Mater., vol. 74, no. May, p.164–175, (2017).

DOI: 10.1016/j.jmbbm.2017.05.027

Google Scholar

[15] K. B. Putra, J. Plott, and A. J. Shih, Biaxial Mooney-Rivlin coefficient of silicone sheet by additive manufacturing,, Procedia CIRP, vol. 65, p.189–195, (2017).

DOI: 10.1016/j.procir.2017.04.049

Google Scholar

[16] R. M. Soares and P. B. Gonçalves, Large-amplitude nonlinear vibrations of a Mooney – Rivlin rectangular membrane,, J. Sound Vib., vol. 333, no. 13, p.2920–2935, (2014).

DOI: 10.1016/j.jsv.2014.02.007

Google Scholar

[17] C. Renaud, J. Cros, Z. Feng, and B. Yang, International Journal of Impact Engineering The Yeoh model applied to the modeling of large deformation contact / impact problems,, Int. J. Impact Eng., vol. 36, no. 5, p.659–666, (2009).

DOI: 10.1016/j.ijimpeng.2008.09.008

Google Scholar

[18] M. Gajewski, Modelling of elastomeric bearings with application of Yeoh hyperelastic material model,, vol. 111, no. TFoCE, p.220–227, (2015).

DOI: 10.1016/j.proeng.2015.07.080

Google Scholar

[19] N. F. A. Manan, Aziz, A.H.A., J. Mahmud, and A. H. Abdullah, Analysis of dryness effect on skin by adapting hyperelastic constitutive model,, (2018).

Google Scholar