Efficient Enantioselective Michael Addition of Nitroalkenes Catalyzed by a New Surfactant-Type Thiourea Organocatalyst in Water

Hong Ying Zhang; Xue Ming Yan

doi:10.4028/www.scientific.net/AMR.1015.602

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Efficient Enantioselective Michael Addition of Nitroalkenes Catalyzed by a New Surfactant-Type Thiourea Organocatalyst in Water

Abstract:

A new surfactant-type bifunctional thiourea organocatalysts were synthesized. In the presence of 10 mol% PhCOOH, the Michael reaction of nitroalkenes with various nucleophiles could be catalyzed smoothly by this new organocatalyst in water at room temperature, giving the desired adducts in good yields with high diastereoselectivities (syn/anti=82/18->99/1) and excellent enantioselectivities (up to 97% ee)

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Periodical:

Advanced Materials Research (Volume 1015)

Pages:

602-605

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1015.602

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Online since:

August 2014

Authors:

Hong Ying Zhang*, Xue Ming Yan

Keywords:

Asymmetric Catalysis, Asymmetric Michael Reaction, Organocatalysis, Surfactant-Type Catalyst

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