Efficient Enantioselective Michael Addition of Nitroalkenes Catalyzed by a New Surfactant-Type Thiourea Organocatalyst in Water

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A new surfactant-type bifunctional thiourea organocatalysts were synthesized. In the presence of 10 mol% PhCOOH, the Michael reaction of nitroalkenes with various nucleophiles could be catalyzed smoothly by this new organocatalyst in water at room temperature, giving the desired adducts in good yields with high diastereoselectivities (syn/anti=82/18->99/1) and excellent enantioselectivities (up to 97% ee)

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Edited by:

Z.S. Liu, L.P. Xu, X.D. Liang, Z.H. Wang and H.M. Zhang

Pages:

602-605

Citation:

H. Y. Zhang and X. M. Yan, "Efficient Enantioselective Michael Addition of Nitroalkenes Catalyzed by a New Surfactant-Type Thiourea Organocatalyst in Water", Advanced Materials Research, Vol. 1015, pp. 602-605, 2014

Online since:

August 2014

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