Synthetic Study towards Aculeatin A and B

Jian Ting Zhang; Cheng Lin Zhu; Shi Peng Chen; Rui Wang; Shuang Ping Huang; Xiao Ji Wang

doi:10.4028/www.scientific.net/AMR.1033-1034.569

Paper Titles

Study on Synthesis of Tert-Butyl(4R)-4-(Methoxymethylcarbamoyl)-2,2-Dimethylthiazolidine-3- Carboxylate
p.555

Synchronous Determination of Copper, Iron, Nickel, Lead, Cadmium and Chromium in Electroplating Wastewater by ICP-AES
p.558

Synthesis of (5R,7R)-Methyl3,5-Dihydroxy-7-((4-Methoxybenzyl)Oxy)Octanoate
p.563

Synthesis of the Key Intermediate of (+)-(6S,2'R)-Cryptocaryalactone
p.566

Synthetic Study towards Aculeatin A and B
p.569

Synthetic Study towards Salvianolic Acid A: Synthesis of the Intermediate of (3, 4-Bis((Tert-Butyldimethylsilyl)Oxy)-Benzylidene)Triphenylphosphorane
p.573

Synthetic Study towards the Total Synthesis of (+)-(6S,2'R)-Cryptocaryalactone
p.576

Improvement on Determination of the Adsorption Value of Activated Carbon on Methylene Blue
p.579

Pressure-Induced Cationic Disordering in Pyrochlore Oxides (La_1-xCe_x)₂Zr₂O₇ and Enhancement of Compressibility
p.583

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 1033-1034Synthetic Study towards Aculeatin A and B

Synthetic Study towards Aculeatin A and B

Abstract:

A practical and diastereoselective synthetic study towards the cytotoxic and antimalarial compounds aculeatin A and B is described, which started from commercially available 1-tetradecanol and proceeded through a key Evans aldol reaction.

You might also be interested in these eBooks

Advances in Chemical Engineering and Advanced Materials IV

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 1033-1034)

Pages:

569-572

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1033-1034.569

Citation:

Cite this paper

Online since:

October 2014

Authors:

Jian Ting Zhang, Cheng Lin Zhu, Shi Peng Chen, Rui Wang, Shuang Ping Huang, Xiao Ji Wang

Keywords:

Aculeatins, Antimalarial, Polyspiroketal Skeleton

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] Examples of synthetic approaches to aculeatins: (a) Wong, Y. S. Chem. Commun. 2002, 686; (b) Falomir, E.; Alvarez-Bercedo, P.; Carda, M.; Marco, J. A. Tetrahedron Lett. 2005, 46, 8407; (c) Malathong, V.; Rychnovsky, S. D. Org. Lett. 2007, 9, 4757; (d) Baldwin, J. E.; Adlington, R. M.; Sham, V. W. W.; Marquez, R.; Bulger, P. G. Tetrahedron 2005, 61, 2353; (e) Suresh, V.; Jon Paul Selvam, J.; Rajesh, K.; Venkateswarlu, Y. Tetrahedron: Asymmetry 2008, 19, 1508; (f) Chandrasekhar, S.; Rambabu, C.; Shyamsunder, T. Tetrahedron Lett. 2007, 48, 4683; (g) Peuchmaur, M.; Wong, Y. S. J. Org. Chem. 2007, 72, 5374.

DOI: 10.1016/j.tetlet.2005.09.146

Google Scholar

[2] Heilmann, J.; Mayr, S.; Brun, R.; Rali, T.; Sticher, O. HelV. Chim. Acta 2000, 83, 2939–2945.

DOI: 10.1002/1522-2675(20001108)83:11<2939::aid-hlca2939>3.0.co;2-n

Google Scholar

[3] Heilmann, J.; Brun, R.; Mayr, S.; Rali, T.; Sticher, O. Phytochemistry 2001, 57, 1281–1285.

DOI: 10.1016/s0031-9422(01)00174-1

Google Scholar

[4] Falomir, E.; Alvarez-Bercedo, P.; Carda, M.; Marco, J. A. Tetrahedron Lett. 2005, 46, 8407.

Google Scholar

[5] Salim, A. A.; Su, B. -N.; Chai, H. -B.; Riswan, S.; Kardono, L. B. S.; Ruskandi, A.; Farnsworth, N. R.; Swanson, S. M.; Kinghorn, A. D. Tetrahedron Lett. 2007, 48, 1849–1853.

DOI: 10.1016/j.tetlet.2007.01.017

Google Scholar

[6] Chin, Y. -W.; Salim, A. A.; Su, B. -N.; Mi, Q.; Chai, H. -B.; Riswan, S.; Kardono, L. B. S.; Ruskandi, A.; Farnsworth, N. R.; Swanson, S. M.; Kinghorn, A. D. J. Nat. Prod. 2008, 71, 390–395.

DOI: 10.1021/np070584j

Google Scholar