Synthesize of Carboxymethyl Chitosan-Graft-Polycaprolactone (CMCS-g-PCL) and the Preparation of Micelles

Meng Ru Zhang; Heng Xu; Mei Dong Lang

doi:10.4028/www.scientific.net/AMR.1120-1121.909

Paper Titles

Adsorption and Dehydration of Water Molecules from α, β and γ Cyclodextrins — A Study by TGA Analysis and Gravimetry
p.886

Production of Cellulase by Aspergillus niger FC-1 and its Application in Hydrolysis of Corncob Residues
p.891

Lycopene Nanoparticles Coated with Microemulsions to Improve Stability
p.897

Synthesis of Hybrid Fe₃O₄–Silica–M(Zn, Cu, Ni) Submicrospheres and its Application for Adsorption on Bovine Hemoglobin
p.903

Synthesize of Carboxymethyl Chitosan-Graft-Polycaprolactone (CMCS-g-PCL) and the Preparation of Micelles
p.909

Characterization and Study on In Vitro Release of Praziquantel from Poly(lactide-co-glycolide) Implants
p.915

Antioxidant Properties of Extracts from Curcuma zedoaria Rhizome
p.920

The Influence of Replant Stress on Hormone and Absorption of Root for Different Apple Rootstocks
p.926

Finite Element Simulation of Pore Morphology and Stress Distribution of Porous Titanium
p.932

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 1120-1121Synthesize of Carboxymethyl...

Synthesize of Carboxymethyl Chitosan-Graft-Polycaprolactone (CMCS-g-PCL) and the Preparation of Micelles

Abstract:

In this study, we synthesized carboxymethyl chitosan-graft-poly(ε-caprolactone) (CMCS-g-PCL) by grafting ε-CL onto the hydroxyl groups of CMCS via ring-opening polymerization. The graft copolymers were characterized by ¹H NMR spectroscopy and thermogravimetric analysis (TGA). Then use the graft copolymer to produce the micelle by solvent-evaporation method. The DLS and TEM were utilized to evaluate the particle size and morphology and showed that the micelles were in a well-defined spherical shape with a uniform size distribution. The results indicated that the size of range is below 200 nm and could be used as drug carrier and have better active cellular uptake.

You might also be interested in these eBooks

Contemporary Approaches in Material Science and Materials Processing Technologies

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 1120-1121)

Pages:

909-914

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1120-1121.909

Citation:

Cite this paper

Online since:

July 2015

Authors:

Meng Ru Zhang, Heng Xu, Mei Dong Lang*

Keywords:

Carboxymethyl Chitosan, Graft Polymer, Micelle, PCL

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] X. J. Huang, Y. Xiao, M. D. Lang, Self-assembly of pH-sensitive mixed micelles based on linear and star copolymers for drug delivery, J. Colloid. Interface. Sci. 364 (2011) 92-99.

DOI: 10.1016/j.jcis.2011.08.028

Google Scholar

[2] Gre´gory F. Schneider, Vladimir Subr, Karel Ulbrich, G. Decher, Multifunctional Cytotoxic Stealth Nanoparticles. A Model Approach with Potential for Cancer Therapy, Nano Letters, 9 (2009) 636-642.

DOI: 10.1021/nl802990w

Google Scholar

[3] H. C. Ge, D. K. Luo, Preparation of carboxymethyl chitosan in aqueous solution under microwave irradiation, Carbohydrate Research. 340 (2005) 1351-1356.

DOI: 10.1016/j.carres.2005.02.025

Google Scholar

[4] L. Upadhyaya, J. Singh, V. Agarwal, R. P. Tewari, Biomedical applications of carboxymethyl chitosans, Carbohydr Polym, 91 (2013), 452-466.

DOI: 10.1016/j.carbpol.2012.07.076

Google Scholar

[5] J. Zhou, C. Elson, T. D. G. Lee, Reduction in postoperative adhesion formation and re-formation after an abdominal operation with the use of N, O-carboxymethyl chitosan, Surgery. 135(2004) 307-312.

DOI: 10.1016/j.surg.2003.07.005

Google Scholar

[6] M. A. Woodruff, D.W. Hutmacher, The return of a forgotten polymer-Polycaprolactone in the 21st century, Progress in Polymer Science. 35 (2010) 1217-1256.

DOI: 10.1016/j.progpolymsci.2010.04.002

Google Scholar

[7] J. L. Yan, Y. Zhang, Y. Xiao, Y. Zhang, M. D. Lang, Novel poly(ε-caprolactone)s bearing amino groups: Synthesis, characterization and biotinylation, Reactive and Functional Polymers. 70 (2010) 400-407.

DOI: 10.1016/j.reactfunctpolym.2010.03.008

Google Scholar

[8] H. Feng, C. M. Dong, Preparation and characterization of chitosan-graft-poly (ϵ-caprolactone) with an organic catalyst, Journal of Polymer Science Part A: Polymer Chemistry. 44(2006) 5353-5361.

DOI: 10.1002/pola.21625

Google Scholar

[9] G. E. Luckachan, C. K. S. Pillai, Chitosan/oligo L-lactide graft copolymers: Effect of hydrophobic side chains on the physico-chemical properties and biodegradability, Carbohydrate Polymers. 64 (2006) 254-266.

DOI: 10.1016/j.carbpol.2005.11.035

Google Scholar

[10] M. Fujioka, H. Okada, Y. Kusaka, S. Nishiyama, H. Noguchi, S. Ishii, Y. Yoshida, Enzymatic Synthesis of Chitin- and Chitosan-graft-Aliphatic Polyesters, Macromolecular Rapid Communications. 25 (2004) 1776-1780.

DOI: 10.1002/marc.200400288

Google Scholar

[11] Y. I. Jeong, S. G. Jin, I. Y. Kim, J. Pei, M. Wen, T. Y. Jung, K. S. Moon, S. Jung, Doxorubicin-incorporated nanoparticles composed of poly(ethylene glycol)-grafted carboxymethyl chitosan and antitumor activity against glioma cells in vitro, Colloids Surf B Biointerfaces. 79 (2010).

DOI: 10.1016/j.colsurfb.2010.03.037

Google Scholar

[12] G. H. Gu, V. Le, M. D. Lang, J. W. Liu, Preparation of polysaccharide derivates chitosan-graft-poly(ε-caprolactone) amphiphilic copolymer micelles for 5-fluorouracil drug delivery, Colloids Surf B Biointerfaces. 116 (2014) 745-750.

DOI: 10.1016/j.colsurfb.2014.01.026

Google Scholar