Characterization and Study on In Vitro Release of Praziquantel from Poly(lactide-co-glycolide) Implants

Li Xia Ma; Zhi Qiang Fei; Chuan Dong Wang; Yang Liu; Xu Du; Qin Wang

doi:10.4028/www.scientific.net/AMR.1120-1121.915

Paper Titles

Production of Cellulase by Aspergillus niger FC-1 and its Application in Hydrolysis of Corncob Residues
p.891

Lycopene Nanoparticles Coated with Microemulsions to Improve Stability
p.897

Synthesis of Hybrid Fe₃O₄–Silica–M(Zn, Cu, Ni) Submicrospheres and its Application for Adsorption on Bovine Hemoglobin
p.903

Synthesize of Carboxymethyl Chitosan-Graft-Polycaprolactone (CMCS-g-PCL) and the Preparation of Micelles
p.909

Characterization and Study on In Vitro Release of Praziquantel from Poly(lactide-co-glycolide) Implants
p.915

Antioxidant Properties of Extracts from Curcuma zedoaria Rhizome
p.920

The Influence of Replant Stress on Hormone and Absorption of Root for Different Apple Rootstocks
p.926

Finite Element Simulation of Pore Morphology and Stress Distribution of Porous Titanium
p.932

Effect of Mn on the Microstructure and Hardness of Gear Steel Treated by Quenching and Partitioning Process
p.939

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 1120-1121Characterization and Study on In Vitro Release of...

Characterization and Study on In Vitro Release of Praziquantel from Poly(lactide-co-glycolide) Implants

Abstract:

A series praziquantel-loaded poly(lactide-co-glycolide) implants are prepared by melt extrusion. The morphologies, structures and the in vitro releases are investigated. The results show that PZQ is dissolved or dispersed in the PLGA matrix and its crystal structure can be transformed into amorphous filament or flake-like structure. The in vitro release increased with the increase of the amount of low molecular weight PLGA0.13. The release of PZQ from the implant with a length of 20 mm is faster than that from that with a length of 10 mm. The macroscopic change and release curves of the implants reveal the drug release from the implants can be controlled by initial diffusion of drug from near the surface of implants followed by elution during polymer erosion.

You might also be interested in these eBooks

Contemporary Approaches in Material Science and Materials Processing Technologies

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 1120-1121)

Pages:

915-919

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1120-1121.915

Citation:

Cite this paper

Online since:

July 2015

Authors:

Li Xia Ma, Zhi Qiang Fei, Chuan Dong Wang, Yang Liu, Xu Du, Qin Wang*

Keywords:

Implant, In Vitro Release, Poly (Lactide-Co-Glycolide), Polymer Erosion, Praziquantel

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] D. H. G. Wegner, Trial designs for multicentre clinical studies of investigational phases Ⅰb to Ⅲ with praziquantel, Arzneimittel forschung., vol. 31, pp . 566-567, (1981).

Google Scholar

[2] D. Cioli, L. Picamattocia, Praziquantel, Parasitol. Res., vol. 90, pp.3-9, (2003).

Google Scholar

[3] J. Pellegrino, F. F. Lima-Costa, M. A. Carlos, R. T. Mello, Experimental chemotherapy of schistosomiasis mansoni. XIII. Activity of praziquantel, an isoquinoline-pyrazino derivative, on mice, hamsters and cebus monkeys, Z. Parasitenkd., vol. 52, pp.151-168, (1997).

DOI: 10.1007/bf00389900

Google Scholar

[4] H. Mehlhorn, B. Becket, P. Andrews, H. Thomas, J. K. Frenkel, In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni. A light and electron microscopic study, Arzneimittel Forschung., vol. 31, pp.544-554, (1981).

Google Scholar

[5] W. Jiao, C. Fu, Q. Qu, Nurbek, S. Xu, L. F. Sun, X. K. Han, Muhan, L. L. Han, Irixiati, J. Peng, K. J. Zhang, Islayin, J. J. Chai, Epidemiological evaluations of the efficacy of slow-released praziquantel-medicated bars for dogs in the prevention and control of cystic echinococcosis in man and animals, Parasitology International, vol. 54, pp.231-236, (2005).

DOI: 10.1016/j.parint.2005.06.002

Google Scholar

[6] L. Cheng, S. R. Guo, W. P. Wu, Characterization and in vitro release of praziquantel from poly(ε-caprolactone) implants, International Journal of Pharmaceutics, vol. 377, pp.112-119, (2009).

DOI: 10.1016/j.ijpharm.2009.05.007

Google Scholar

[7] L. Cheng, L. Lei, S. R. Guo, In vitro and in vivo evaluation of praziquantel loaded implants based on PEG/PCL blends, International Journal of Pharmaceutics, vol. 387, pp.129-138, (2010).

DOI: 10.1016/j.ijpharm.2009.12.010

Google Scholar

[8] L. X. Ma, Y. Liu, C. D. Wang, Q. Wang, Determination and release rate of veterinary sustained-released praziquantel-PLGA implants, Chinese Journal of Veterinary Drug, vol. 47, pp.42-45, (2013).

Google Scholar

[9] M. V. Chaud, A. C. Lima, M. M. Vila, M. O. Paganelli, F. C. Paula, L. N. Pedreiro, M. P. D. Gremiao, Development and evaluation of praziquantel solid dispersions in sodium starch glycolate, Tropical Journal of Pharmaceutical Research, vol. 12, pp.163-168, (2013).

DOI: 10.4314/tjpr.v12i2.5

Google Scholar