The Role of Adhesion in Gold Nanoparticles for Cancer Detection and Treatment

Abstract:

This paper presents the results of an experimental study of the effects of adhesion between gold nanoparticles and surfaces that are relevant to the potential applications in cancer detection and treatment. Adhesion is measured using a dip coating/atomic force microscopy (DC/AFM) technique. The adhesion forces are obtained for dip-coated gold nanoparticles that interact with peptide or antibody-based molecular recognition units (MRUs) that attach specifically to breast cancer cells. They include MRUs that attach specifically to receptors on breast cancer cells. Adhesion forces between anti-cancer drugs such as paclitaxel, and the constituents of MRU-conjugated Au nanoparticle clusters, are measured using force microscopy techniques. The implications of the results are then discussed for the design of robust gold nanoparticle clusters and for potential applications in localized drug delivery and hyperthermia.

• Periodical: Advanced Materials Research (Volume 1132)
• Pages: 72-86
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1132.72
• Online since: December 2015
• Authors: Y. Oni, J.D. Obayemi, K. Kao, S. Dozie-Nwachukwu, S. Odusanya, Nicolas Anuku, W.O. Soboyejo*
• Keywords: Adhesion, Anti-Cancer Drugs, Cancer Detection, Gold Nanoparticles, Treatment

References

[1] L. A. Nagahara, M. Ferrari, and P. Grodzinski, MRS Bull. 34, 406–414 (2009).

[2] P. Grodzinski, M. Silver, and L. K. Molnar, Expert Rev. Mol. Diagn. 6, 307–318 (2006).

[3] D. Irvine, L. Vincent, J. E. Graydon, N. Bubela, and L. Thompson, Cancer Nursing 17(5), 367–378 (1994).

[4] Le Cancer Dans le Monde edited by B. W. Stewart and P. Kleihues (C.I. d.R. s.I.C. (CIRC), IARC Press, Lyon, 2005).

[5] A. Jemal, M. J. Thun, L. A. G. Ries, H. L. Howe, H. K. Weir, M. M. Center, E. Ward, X. C. Wu, C. Eheman, A. Anderson, U. A. Ajani, B. Kohler, and B. K. Edwards, J. Nat. Cancer Inst. 100, 1672–1694 (2008).

DOI: 10.1093/jnci/djn389

[6] Y. Oni, C. Theriault, A. V. Hoek, and W. O. Soboyejo, Mater. Sci. Eng. C 31(2), 67–76 (2011).

[7] R. Kurzrock and M. Markman, Targeted Cancer Therapy (Humana Press, Clifton, 2008).

[8] M. P. Melancon, W. Lu, and C. Li, MRS Bull. 34, 415–421 (2009).

[9] M. Ferrari, Nat. Rev. Cancer 5, 161–171 (2005).

[10] M. V. Yezhelyev, X. Gao, Y. Xing, A. Al-Hajj, and O'. R. M. Nie Shuming, Lancet Onco 7(8), 657–667 (2006).

[11] R. G. Ramachandra, S. Mahaveer, and B. D. Ross, Clini. Can. Res. 12, 6677 (2006).

[12] D. L. Thorek and A. Tsourkas, Biomaterials 29(26), 3583–3590 (2008).

[13] A. H. Lu, E. L. Salabas, and F. Schuth, Angew Chem. Int. Ed. Engl. 46(8), 1222–1244 (2007).

[14] S. Laurent, D. Forge, M. Port, A. Roch, C. Robic, L. Vander Elst, and R. N. Muller, Chem. Rev. 108, 2064–2110 (2008).

DOI: 10.1021/cr068445e

[15] Kim, S. Park, E. L. Ji, S. M. Jin, J. H. Lee, L. S. Lee, I. Yang, J. S. Kim, S. K. Kim, M. H. Cho, and T. Hyeon, Angew. Chem. Int. Ed. 45(46), 7754–7758 (2006).

DOI: 10.1002/anie.200602471

[16] W. St€ober, A. Fink, and E. Bohn, J Colloid Interface Sci. 26(1), 62–69 (1968).

[17] S. I. Stoeva, F. Huo, J. S. Lee, and C. A. Mirkin, J. Am. Chem. Soc. 127(44), 15362–15363 (2005).

DOI: 10.1021/ja055056d

[18] V. Salgueirino-Maceira, M. A. Correa-Duarte, M. Farle, A. Lopez-Quintela, K. Sieradzki, and R. Diaz, Chem. Mater. 18(11), 2701–2706 (2006).

DOI: 10.1021/cm0603001

[19] M. Chen, Y. N. Kim, H. M. Lee, C. Li, and S. O. Cho, Phys. Chem. C 112, 8870–8874 (2008).

[20] H. Wang, D. W. Brandt, F. Le, P. Nordlander, and N. J. Halas, Nano. Lett. 6(4), 827–832 (2006).

[21] L. Wang, J. Bai, Y. Li, and Y. Huang, Angew. Chem. Int. Ed. Engl. 47(13), 2439–2442 (2008).

[22] G. Binnig, C. F. Quate, and Ch. Gerber, APS J. Phys. Rev. Lett. 56, 930–933 (1986).

DOI: 10.1103/physrevlett.56.930

[23] R. Wiesendanger, Scanning Probe Microscopy and Spectroscopy: Methods and Applications (Cambridge University Press, Cambridge, 1994).

[24] S. N. Magonov and M. H. Whangbo, Surface Analysis with STM and AFM: Experimental and Theoretical Aspects of Image Analysis (VCH, Weinheim, 1996).

DOI: 10.1002/9783527615117

[25] J. Meng, E. Paetzell, A. Bogorad, and W. O. Soboyejo, J. Appl. Phys. 107, 114301 (2010).

[26] C. B. Prater, P. G. Maivald, K. J. Kjoller, and M. G. Heaton, Force Spectroscopy, See www. braker. com.

[27] P. G. Hartley, F. Grieser, P. Mulvaney, and G. W. Stevens, Langmuir 15, 7282–7289 (1999).

[28] H. J. Butt, B. Cappella, and M. Kappl, Surf. Sci. Rep. 59, 1–152 (2005).

[29] C. C. Berry and A. S. G. Curtis, J. Phys. D: Appl. Phys. 36, R 198 (2003).

[30] P. Hinterdorfer, G. Sch€utz, F. Kienberger, and H. Schindler, Rev. Mol. Biotechnol. 82, 25 (2001).

[31] V. Dupres, F. D. Menozzi, C. Locht, B. H. Clare, N. L. Abbott, S. Cuenot, C. Bompard, D. Raze, and Y. F. Dufrene, Nat. Methods 2, 515–520 (2005).

DOI: 10.1038/nmeth769

[32] E. Wojcikiewicz, X. Zhang, and V. Moy, Biol. Proced. Online 6, 1–9 (2004).

[33] F. Li, S. D. Redick, H. P. Erickson, and V. T. Moy, Biophys. J. 84, 1 252–1262 (2003).

[34] W. R. Miller, W. N. Scott, R. Morris, H. M. Fraser, and R. M. Sharpe, Nature 313, 231–233 (1985).

[35] D. P. Zelinski, N. D. Zantek, J. C. Stewart, A. R. Irizarry, and M. S. Kinch, Cancer Res. 61, 2301–2306 (2001).

[36] K. V. Wolf, Z. Zong, J. Meng, A. Orana, N. Rahbar, K. M. Balss, G. Papandreou, C. A. Maryanoff, and W. Soboyejo, Biomed. Mater. Res. Part A 87A, 272–281 (2008).

DOI: 10.1002/jbm.a.31860

[37] J. L. Hutter and J. Bechhoefer, Rev. Sci. Instrum. 64, 1868–1873 (1993).

[38] G. A. Matei, E. J. Thoreson, J. R. Pratt, D. B. Newell, and N. A. Burnham, Rev. Sci. Instrum. 77, 083703 (2006).

[39] B. Bhushan, Handbook of Micro/Nanotribology (CRC, Boca Raton, 1995).

[40] R. G. Pearson, Struct. Bonding 80, 1–10 (1993).

[41] A. Kassam, G. Bremner, B. Clark, and B. R. Lennox, J. Am. Chem. Soc. 128(11), 3476–3477 (2006).

[42] Z. M. Fresco and J. M. J. Frechet, J. Am. Chem. Soc. 127(23), 8302–8303 (2005).

[43] N. Ohmura, K. Tsugita, J. I. Koizumi, and H. Saika, J. Bacteriol. 178(19), 5776–5780 (1996).

DOI: 10.1128/jb.178.19.5776-5780.1996