Assessments on the Antibacterial Activity of DL-Valinium Maleate Compound and Z-Scan Analysis

Abstract:

DL-valinium maleate [DLVM] compound was grown as single crystals at room temperature by gradual evaporation from an aqueous solution. The classical nucleation theory was examined to maximize the growth conditions for producing high-quality crystals, Nucleation kinetics studies reveal that the crystal has been grown at room temperature 313 K for which predicted critical supersaturation is 6.19. The grown compound DLVM crystallized in a triclinic system with a centrosymmetric space group P1, according to single crystal and powder X-ray diffraction experiments. The lattice parameters were calculated as a= 6.17 Å, b= 9.68 Å, c= 10.59 Å, α= 105.75°, β = 105.67º and γ = 104.69° with unit cell volume 548.2 ų. The presence of functional groups in the grown compound has been identified by using Fourier Transform Infrared [FTIR] experiments. NMR studies were used to examine the structural features of DLVM compounds. Since the grown material belongs to the centrosymmetric space group, the material has been found to exhibit third-order NLO property. The Z-scan technique was used to analyse the third-order nonlinear behaviour of the grown crystal. The technique was very useful in evaluating the nonlinear refractive index n₂, absorption co-efficient β, and nonlinear optical susceptibility χ⁽³⁾ of the grown material. Hence, the grown crystal finds useful applications in optoelectronics. The antibacterial activity of the title compound was also studied by using the Agar disc diffusion method against the standard bacteria Klebsiella pneumonia, Staphylococcus aureus and Enterococcus faecalis. The results of the antibacterial activity experiment show that the synthesized DLVM crystal will be a good option for the creation of antibiotic medicines that will combat the tested bacterial strains.

• Periodical: Advanced Materials Research (Volume 1183)
• Pages: 47-57
• DOI: https://doi.org/10.4028/p-BCuZj2
• Online since: March 2025
• Authors: S. Azhagiri, P. Vasudevan*, D. Jayaraman, A. Vichithra
• Keywords: Anti-Bacterial Activity, DL-Valinium Maleate, FTIR, NMR, Single Crystal, XRD Studies, Z-Scan Technique

References

[1] T. Thilak, G. Marudhu, V. Chithambaram, D. Saravanan, T. Baraniraj, Investigating third order nonlinear optical properties of potassium dichromate –doped L-alanine (LAKDC) single crystal using Z-scan technique, Appl. Phy. B. 129 (2023) 77-83.

DOI: 10.1007/s00340-023-08020-z

[2] A. M. Hidayathullah, R. Samuel, V. Chithambaram, R. Raja, S. Janarthanan , Investigations on the synthesis and growth and structural, spectral, optical, mechanical and thermal properties of non-linear optical single crystals of Bis-L-Seriniumoxalate Dihydrate (BLSOD), J. Ovonic Res. 19 (2023) 43-52.

DOI: 10.15251/jor.2023.191.43

[3] R. Santhakumari, K. Ramamurthi, R. Ramesh Babu, Helen Stoekli Evans, Bhagavannarayana G, Hema R, Growth and characterization of thiosemicarbazide hydrochloride: a semiorganic NLO material, Spectrochim. Acta A Mol. Bio. Mol. Spectrosc. 82 (2011) 102-107.

DOI: 10.1016/j.saa.2011.07.007

[4] T. Sivaranajani, T. Jayavarthanan, S. Suresh, C. S. Biju, A. Jayanthi, L. Sangeetha, C. Saveetha, A. Alfind Paul Frit and M. Muruganandam M, Vibrational spectra and quantum chemical investigations on nicotinium nitrate monohydrate single crystal for anti-bacterial studies, Chem. Phy. Impact. 6 (2023) 100200.

DOI: 10.1016/j.chphi.2023.100200

[5] Michal Abendrot, Liliana Checinska, Joachim Kusz, Katarzyna Lisowska, Katarzyna Zawadzka, Aleksandra Felczak and Urszula Kalinowska, Zinc(II) Complexes with Amino Acids for Potential Use in Dermatology: Synthesis, Crystal Structures, and Antibacterial Activity, Mol. 25 (2020) 951-968.

DOI: 10.3390/molecules25040951

[6] S. V. Ashvin Santhiaa, B. Aneebab, S. Vinuc, Alaa Baazeemd, R. Sheela Christy, J. King. Saud. Univ. Sci. 33 (2021) 101498.

[7] T. Gubendiran, M. Lenin, G. Sathish kumar, B. Sathiyamoorthy, S. Nithiyanantham and P. Ramasamy, Synthesis, Growth and Investigation of Optical and Thermal Properties of Urea –L-Maleic Acid, A Versatile Organic Nonlinear Optical Single Crystal, Chem. Afr. 6(2023) 1429-1435.

DOI: 10.1007/s42250-023-00588-5

[8] S. Janet Priyavathani, S. Stella Mary, S. Sahaya Jude Dhas, P. Gandhimathi, S. Usharani, Structural, optical, magnetic and thermal properties of L-methionine succinic acid single crystal for photonic applications, Chem. Phy. Impact. 6 (2023) 100203.

DOI: 10.1016/j.chphi.2023.100203

[9] S. Kavitha, R. Ezhil Vizhi, Studies on synthesis, structural, thermal, optical, spectral and mechanical properties of an inorganic strontium nitrate NLO single crystal, J. Mol. Struct. 1276(2023) 134746.

DOI: 10.1016/j.molstruc.2022.134746

[10] Shanmugam Akilandeshwari, Lakshmana Jothi, Walid F. Elkatib, Eman Fayad, Ola A. Abu Ali, and Garieb S.EI-Sayyad, Synthesis, Spectroscopic, Optical, Thermal and mechanical characterization of nonlinear proline oxalate Single crystals, Opt. Quant. Electron. 55(2023) 14.

DOI: 10.1007/s11082-022-04241-2

[11] David Willington T, Sindhusha S, Joema S E and Marshan Robert H, Experimental and theoretical approaches of nonlinear optical active 4-aminopyridinium hydrogen maleate single crystal for laser assisted opto-electronic applications, J. Cyst. Grow. 589(2022) 126686.

DOI: 10.1016/j.jcrysgro.2022.126686

[12] Dessale Alemu Fentaw M, Esthaku Peter and Tizazu Abza, Synthesis and characterization of lanthanum chloride doped L-alanine maleate single crystals, J. Cryst. Grow. 522(2019) 1-4.

DOI: 10.1016/j.jcrysgro.2019.06.002

[13] J. Suresh, S. Natarajan, DL-Valinium trifluoroacetate, Acta Cryst. E62(2006) 3331-3333.

[14] N. Srinivasan, B. Dalhus, R. K. Rajaram, DL-Valinium perchlorate, Acta Cryst. E59(2003) 28-30.

[15] N. Srinivasan, B. Sridhar, R. K. Rajaram, DL-Valinium nitrate, Acta Cryst. E58(2002) 95-97.

[16] K. Anitha, S. Annavenu, B. Sridhar, R. K. Rajaram, DL-Valine DL-valinium picrate, Acta Cryst. E60(2004) 1722-1724.

DOI: 10.1107/s1600536804021877

[17] B. S. Ravikumar, B. Sridhar, R. K. Rajaram, DL-Valinium dihydrogen phosphate, Acta Cryst. E58(2002) 879-881.

[18] K. Rajagopal, R. V. Krishna Kumar, M. Subha Nandhini, A. Mostad, S. Natarajan, DL-Valinium trichloroacetate at 123 K, Acta Cryst. E58(2002) 279-281.

DOI: 10.1107/s1600536802002751

[19] A. C. Zettlemoyer, Nucleation, Dekker. New York: 1969.

[20] J. C. Brice, The growth of crystals from Liquids, Wiley; New York: 1972.

[21] M. Alagar, R. V. Krishnakumar, A. Mostad, S. Natarajan, DL-Valinium maleate at 150 K Acta Cryst. E57 (2001) 1102-1104.

DOI: 10.1107/s1600536801017391

[22] S. Pandiarajan, M. Umadevi, R. K. Rajaram, V. Ramakrishnan, Infrared and Raman spectroscopic studies of l-valine l-valinium perchlorate monohydrate, Spectrochim. Acta. A62(2005) 630-636.

DOI: 10.1016/j.saa.2005.02.008

[23] M. B. Mary, S. Sasirekha, V. Ramakrishnan, Vibrational spectral analysis of DL-valine DL-valinium and DL-methionine DL-methioninium picrates, Spectrochim. Acta. A 65(2006) 955-963.

DOI: 10.1016/j.saa.2006.01.043

[24] E. Ramachandran, S. Natarajan, Synthesis of L-valine crystals, Cryst. Res. Technol. 44(2009) 641-646.

DOI: 10.1002/crat.200900012

[25] B. Thirumalaiselvam, R. Kanagadurai, D. Jayaraman, V. Natarjan, Growth and characterization of 4-methyl benzene sulfonamide single crystals, Opt. Mater. 37 (2014) 74-79.

DOI: 10.1016/j.optmat.2014.05.002

[26] Ready J F, Industrial applications of laser. 2nd edition Academic Press, Sandiego, 1978.

[27] S. Q. Chen, Z. B Liu, W. P. Zang, J. G. Tian, W. Y. Zhou, F. Song, C. P. Song, Study on Z-scan characteristics for a large nonlinear phase shift, Opt. Soc. Am. B 22 (2005) 1911-1916.

DOI: 10.1364/josab.22.001911

[28] S. Zainab. H. Sadik, Dhia H Al-Amiedy, Amal F Jaffar, Third Order Optical Nonlinearities of C450 Doped Polymer Thin Film Investigated by the Z-Scan, Adv. Mater. Phy. Chem. 2 (2012) 43-49.

DOI: 10.4236/ampc.2012.21007