Carboxymethyl Chitosan/Hydroxyapatite Composite Scaffold for Bone Regeneration

Abstract:

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Natural bone is a composite mainly made from nano/micro-structure of hydroxyapatite and collagen fibers. For bone regeneration by tissue engineering, it is important to synthesize nano-composites with good biocompatibility, high bioactivity and great bonding property as potentially useful scaffold. In this study, we fabricated chitosan nano-nonwoven scaffold via electrospinning and modified chitosan scaffolds by carboxymethylation (CM). Moreover scaffolds were macerated in SBF (simulated body fluid) to form hydroxyapatite on its surface. Surface morphologies (SEM) showed that nano/micro particles formed on the surface of the carboxymethyl chitosan fibrous scaffold. Results of FT-IR and XRD confirmed that the nano/micro particles were hydroxyapatite crystalline. Moreover by employed mice osteoblast (MC3T3-E1) cell for adhesion, proliferation and differentiation assays, and the hydroxyapatite particles appeared to have a great effect on the late stages of osteoblast behavior (alkaline phosphatase ).

Info:

Periodical:

Advanced Materials Research (Volumes 123-125)

Edited by:

Joong Hee Lee

Pages:

299-302

DOI:

10.4028/www.scientific.net/AMR.123-125.299

Citation:

X. X. Bao et al., "Carboxymethyl Chitosan/Hydroxyapatite Composite Scaffold for Bone Regeneration", Advanced Materials Research, Vols. 123-125, pp. 299-302, 2010

Online since:

August 2010

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Price:

$35.00

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