Taurine Induces the Apoptosis in Pulmonary Artery Smooth Muscle Cell

Abstract:

As an endogenous anti-damage material in organism, Taurine (Tau) stems from food and almost resides in all animals’ cells by means of liberation，which could be found in diverse biological actions, including protection against ischemia-reperfusion injury, modulation of intracellular calcium concentration, and antioxidant, and blood pressure-lowering effects[1]. It also has an effect that inducing apoptosis in certain kinds of cells. Our results showed that Tau can degrade cell viability, mitochondrial potentials, and the expression of Procasepase-9 in PASMCs. In conclusion, Tau induces apoptosis in PASMCs through mitochondrial-dependent pathway.

• Periodical: Advanced Materials Research (Volumes 183-185)
• Pages: 937-941
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.183-185.937
• Online since: January 2011
• Authors: Xiao Dan Zhang, Jie Jing Sheng, Feng Hua Zhao, Da Ling Zhu
• Keywords: Apoptosis, Mitochondrial-Dependent Pathway, Pulmonary Artery Smooth Muscle Cells, Taurine

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