Study on the Inclusion Behavior of Cucurbit [n] uril with Phenylalanine
The characteristics of host-guest complexes between cucurbit[n]uril (CB [n]) and phenylalanine were investigated by UV-visible absorption spectroscopy in acetate buffer solution at room temperature. It was found that the UV-visible absorption increased steadily with constantly dropping the high concentration of cucurbituril (CB ) and cucurbituril (CB ) in the phenylalanine solution which indicates that there are some interaction betweenCB [n] and phenylalanine.Then CB  and phenylalanine at molar ratio of 1:1 to weigh while CB  and phenylalanine at molar ratio of 1:2, respectively, are both demonstrated by 1H NMR spectra. 1H NMR spectrum of complexes was obtained, indicating an enthalpic driving force for host-guest complexes. The possible interaction mechanism and inclusion mode were also discussed. This work may extend the application range of CB [n] in supramolecular and pharmaceutical analysis.
Huaiying Zhou, Tianlong Gu, Daoguo Yang, Zhengyi Jiang, Jianmin Zeng
N. Chen and Y. B. Li, "Study on the Inclusion Behavior of Cucurbit [n] uril with Phenylalanine", Advanced Materials Research, Vols. 197-198, pp. 1153-1156, 2011