Synthesis of 2-Chloro-4,6-Diamino-5-Cyanopyrimidine and its Amino-Substituted Derivatives

Abstract:

The important pyrimidine intermediate 2-chloro-4,6-diamino-5-cyanopyrimidine was prepared by the cyclization of sodium salt of 1-amino-1-cyanamino-2,2-dicyanoethylene which was obtained from sodium dicyanamide and malononitrile via the nucleophilic addition in good yield and purity. The 4,6-diamino-5-cyanopyrimidines substituted with different amino groups could be synthesized by nucleophilic substitution reaction of amines, and they have good bactericidal activities to some funguses.

• Periodical: Advanced Materials Research (Volumes 233-235)
• Pages: 321-324
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.233-235.321
• Online since: May 2011
• Authors: Hong Mei Yu, Hai Feng Li, Hong Min Jia, Xiu Hui Zhu
• Keywords: Organic Synthesis

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