pH-Controlled Drug Release from Mesoporous Silica Spheres with Switchable Gates

Qiang Gao; Zong Wei Chen; Jun Xu; Yao Xu

doi:10.4028/www.scientific.net/AMR.236-238.2142

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pH-Controlled Drug Release from Mesoporous Silica Spheres with Switchable Gates

Abstract:

Mesoporous silica sphere (MSS) with switchable gates was prepared by the graft of pH-sensitive propyldiethylenetriamine groups (multiamine chains) around mesopore outlets. The textural parameters of the resultant material had been analyzed. In the following test of in vitro drug release, the gated mesoporous material showed high response to solution pH. At high pH (pH 7.5), ibuprofen (IBU) that loaded in this carrier released rapidly and completely (within 2 h); at low pH (pH 4.0 or 5.0), only a small part of the IBU (13 wt%) was slowly released from this carrier and the most of IBU was effectively confined in mesopores.

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Periodical:

Advanced Materials Research (Volumes 236-238)

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2142-2145

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https://doi.org/10.4028/www.scientific.net/AMR.236-238.2142

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Online since:

May 2011

Authors:

Qiang Gao, Zong Wei Chen, Jun Xu, Yao Xu

Keywords:

Drug Release, Mesoporous Material, pH Senstitive, Switchable Gates

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