pH-Controlled Drug Release from Mesoporous Silica Spheres with Switchable Gates
Mesoporous silica sphere (MSS) with switchable gates was prepared by the graft of pH-sensitive propyldiethylenetriamine groups (multiamine chains) around mesopore outlets. The textural parameters of the resultant material had been analyzed. In the following test of in vitro drug release, the gated mesoporous material showed high response to solution pH. At high pH (pH 7.5), ibuprofen (IBU) that loaded in this carrier released rapidly and completely (within 2 h); at low pH (pH 4.0 or 5.0), only a small part of the IBU (13 wt%) was slowly released from this carrier and the most of IBU was effectively confined in mesopores.
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
Q. Gao et al., "pH-Controlled Drug Release from Mesoporous Silica Spheres with Switchable Gates", Advanced Materials Research, Vols. 236-238, pp. 2142-2145, 2011