Synthesis and Crystal Structure of 13-cis-Retinoate Aryl Derivatives
A series of 13-cis-retinoate aryl derivatives were synthesized from 13-cis-retinoic acid and phenols or arylalcohol with dicyclohexylcarbodiimide (DCC) as reagent and 4-dimethylaminopyridine (DMAP) as catalyst. Their structures were characterized by 1H, 13C NMR, IR and MS. The crystal of 3a has been determined by single crystal X-ray diffraction analysis and its molecular structure has been confirmed. Compound 3a belongs to monoclinic system with space group P2 (1)/c, a = 22.235 (3) Å, b = 7.4117 (10) Å, c = 15.990 (2) Å, β = 109.253 (3) °, V = 2487.7 (6) Å3, Z = 4, R = 0.0613, ωR = 0.01437.
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
W. G. Yi et al., "Synthesis and Crystal Structure of 13-cis-Retinoate Aryl Derivatives", Advanced Materials Research, Vols. 236-238, pp. 3037-3040, 2011