(R)-1-Phenylethanol Production from Racemic 1- Phenylethanol by Double Strains Redox-Coupling
A strain S307 that can oxidize selectively (S)- 1-phenylethanol to acetophenone and a strain IS 118 that can asymmetric reduce acetophenone to (R)- 1-phenylethanol were isolated from soil. S307 was identified as a species of Undibacterium belonging to the family Oxalobacteraceae of the Betaproteobacteria. S307. IS 118 was identified as Asperillus tamarii. The oxidation of (R, S)-1- phenylethanol with Undibacterium sp. S307 followed by the reduction of the oxidation mixture with Asperillus tamarii IS 118 to afford (R)-1-phenylethanol was described. The effects of redox-coupling patterns on the product of (R)-1-phenylethanol were investigated. After redox-coupling deracemization, the yield and ee of (R)-1-phenylethanol were 87% and 99% respectively.
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
L. Ma et al., "(R)-1-Phenylethanol Production from Racemic 1- Phenylethanol by Double Strains Redox-Coupling", Advanced Materials Research, Vols. 236-238, pp. 981-985, 2011