Antioxidant Research of Persimmon Extraction in Ionizing Radiatio Mice

Abstract:

Persimmon has good health function. To further investigate the antioxidant function in vivo, we set up a model mice with ionizing radiation. IRC mice were divided randomly into six groups, Blank control group, Model control group, VE control group, Low dosage group (G1), Middle dosage group (G2) and High dosage group (G3) respectively. Orally given persimmon extract for 35 days, mice were treated with γ-rays. Our results indicated that pervious administration of the persimmon extraction obviously increased the liver index of the mice. And pathological inspection by microscope suggested that orally given persimmon extraction obviously protected the liver cells of the mice. Further analysis demonstrated that persimmon extraction decreased the MDA content, and increased the SOD and GSH-PX activity in both the serum and the liver in the mice after the Ionizing radiation. Our results suggested the protection role of persimmon extraction by inhibiting the oxidation reaction in vivo.

• Periodical: Advanced Materials Research (Volumes 343-344)
• Pages: 1198-1206
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.343-344.1198
• Online since: September 2011
• Authors: Xiang Ning Chen, Wan Shan Hu, Yuan Hong Xie, Yu Hua Li, Lin Bo Guo, Wen Bin Jin
• Keywords: Antioxidant, Ionizing Radiation, Mice, Mopan Persimmon

References

[1] Gorinstein S, Kulasek G.W., Bartnikowska E., Leontowicz M., Zemser M., Morawiec M. Trakhtenberg S. 1998. The influence of persimmon peel and persimmon pulp on the lipid metabolism and antioxidant activity of rats fed cholesterol. Nutrition Biochemistry. 9: 223–227.

DOI: 10.1016/s0955-2863(98)00003-5

[2] Gorinstein S., Martin-Belloso O., Park Y.S., Haruenkit R., Lojek A., Caspi A., Libman I. Trakhtenberg T., Comparison of some biochemical characteristics of different citrus fruits, Food Chemistry., vol 74, no 3, August 2001, pp.309-315.

DOI: 10.1016/s0308-8146(01)00157-1

[3] Gorinstein S., Zachwieja Z., Folta M., Barton H., Piotrowiz J., Zemser M., Weisz M. Traktenberg S., M´art´ın-Belloso O. 2001. Comparative contents of dietary fiber, total phenolics and minerals in persimmons and apples. Journal of Agriculture and Food Chemistry. 49: 952–957.

DOI: 10.1021/jf000947k

[4] Kawase M., Motohashi N., Satoh K., Sakagami H., Nakashima H., Tani S., Shirataki Y. Kurihara T., Spengler G., Wolfard K., Molnar J. 2003. Biological activity of persimmon (Diospyros kaki) peel extracts. Phototherapy Research. 17: 495- 500.

DOI: 10.1002/ptr.1183

[5] Lee S.O., Chung S.K., Lee I.S. 2006. Antidiabetic effect of dietary persimmon (Diospyros kaki L. cv. Sangjudunggsi) peel in streptozotocin-induced diabetic rats. Journal of Food Science 71(3): S293–298.

DOI: 10.1111/j.1365-2621.2006.tb15656.x

[6] Ames B.N. 1989. Endogenous oxidative DNA damage, aging and cancer. Free Radical Res Commun. 7: 121-127.

[7] Heinonen M., Lehtonen P.J., Hopia A. 1998. Antioxidative activity of berry and fruit wines and liquor. Journal of Agriculture and Food Chemistry. 46: 25-31.

DOI: 10.1021/jf970489o

[8] Chen X.N., Fan J.F., Yue X., Wu X.R., Li L.T. 2008. Radical scavenging activity and phenolic compounds in Persimmon (Diospyros kaki L. cv. Mopan). Journal of Food Science. 73(1): 24-28.

DOI: 10.1111/j.1750-3841.2007.00587.x

[9] Jung S.T., Park Y.S., Zachwieja Z., Folta M., Barton H., Piotrowicz J., Katrich E., Trakhtenberg S., Gorinsten S. 2005. Some essential phytochenicals and the antioxidant potential in fresh and dried persimmon. Journal of Food Sciences and Nutrition. 56(2): 105-113.

DOI: 10.1080/09637480500081571

[10] Suzuki T., Someya S., Hu F, et al. 2005. Comparative study of catechin compositions in five Japanese persimmons (Diospyros Kaki). Food Chemistry. 93: 149-152.

DOI: 10.1016/j.foodchem.2004.10.017

[11] Hagen S.F., Borge A.G. I, Bengtsson G.B., et al. 2007. Phenolic contents and other health and sensory related properties of apple fruit (Malus domestica Borkh., cv. Aroma): effect of postharvest UV-B irradiation. Postharvest Biology and Technology. 45: 1-10.

DOI: 10.1016/j.postharvbio.2007.02.002

[12] Ahn HS, Jeon T, Lee JY, Hwang SG, Lim Y, Park D. 2002. Antioxidative activity of persimmon and grape seed extract: In vitro and in vivo. Nutrition Research 22 (11): 1265-1273.

DOI: 10.1016/s0271-5317(02)00429-3

[13] Kim S.Y., Jeong S.M., Kim S.J., et al. 2006. Effect of heat treatment on the antioxidatiVE and antigenotoxic activity of extracts from persimmon ( Diospyros kaki L. ) peel. Bioscience Biotechnology Biochemistry 70(4): 999-1002.

DOI: 10.1271/bbb.70.999

[14] Tribble D.L. 1999. Antioxidant Consumption and Risk of Coronary Heart Disease: Emphasis on Vitamin C, Vitamin E, and ß-Carotene. American Heart Association. 99: 591-595.

DOI: 10.1161/01.cir.99.4.591