Preparation and Characterization of Nano-β-Tricalcium Phosphate/Silk Fibroin Scaffold for Tissue Engineering Applications

Abstract:

Silk fibroin (SF) and β-tricalcium phosphate (β-TCP) had been used in biomedical applications for these years. The potential of silk and β-TCP for application in tissue engineering is currently being explored. The purpose of this study was to prepare and characterize a 3D scaffold consisting of nano-β-TCP/SF composite. XRD and FT-IR analysis showed that predominant crystalline phase of calcium phosphate was β-TCP; a chelate effect between SF and Ca²⁺ was happened at complexing period of SF and β-TCP. The compressive strength of nano-β-TCP/SF composite was 42 MPa ± 0.12 MPa. In vitro cell cultivation experiment showed that the composite was a good matrix for the growth of osteoblasts. Conclusion: the incorporation of SF into nano-β-TCP can enhance both mechanical strength and bioactivity of the scaffold, which suggests that the β-TCP/SF composite may be a potential biomaterial for tissue engineering.

• Periodical: Advanced Materials Research (Volumes 343-344)
• Pages: 882-888
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.343-344.882
• Online since: September 2011
• Authors: Jun Ou, Yu Min Jiang, Zhan He Zhang
• Keywords: Scaffold, Silk Fibroin, Tissue Engineering, β-Tricalcium Phosphate

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