Properties of Amorphous Silica Entrapped Isoniazid Drug Delivery System

Abstract:

This work describes the properties of silica drug delivery system (DDS) produced using micelles entrapment approach. Isoniazid, which is a water soluble drug for tuberculosis was used in the system. The effects of synthesis parameters were systematically studied such as synthesis temperature (38-70°C), amount of butanol co-solvent (6-18 ml), and amount of Si organic precursor (2-8 ml). From transmission electron microscope (TEM) images, the size of DDS could be tuned from 21-104 nm by changing the reaction temperature. The increase of butanol co-solvent enlarged the size of DDS in the range of 40-94 nm. A similar trend was observed for DDS with increasing organic Si precursor whereby the particle size could be tuned from 40-132 nm. However, at high organic Si precursor of > 2 ml, a bimodal structure of DDS was observed. Stability study in biological media at 37°C of selected sample showed that the produced DDS had acceptable degree of agglomeration.

• Periodical: Advanced Materials Research (Volume 364)
• Pages: 134-138
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.364.134
• Online since: October 2011
• Authors: Azwana Ab Wab Hajarul, Dyana Zakaria Nor, Azlan Abdul Aziz, Abdul Razak Khairunisak
• Keywords: Amorphous Silica, Drug Delivery System, Isoniazid, Micelles

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DOI: 10.1016/j.jcis.2005.02.019