Synthesis of Fullerene-Acid Conjugates

Abstract:

N-substituted 3,4-fullero pyrrolidine was synthesized according to 1,3-Dipolar cycloaddition of the azomethine ylide. Aspartic acid and glutamic acid with protected α-amino and α-carboxyl groups were reacted with the activated hydroxyl group of N-substituted 3,4-fullero pyrrolidine, respectively. The products were deprotected, affording two novel fullerene α-amino acids, fullerene aspartic acid and fullerene glutamic acid. Their chemical structures were characterized by MALAI-TOF-MS, UV-Vis, FT-IR and 1HNMR. Both fullerene amino acids with a free amino group and a free carboxyl group would have unique property and potential use in medicine and biology. A novel method has been developed to synthesize fullerene conjugate. Their unique chemical structures make them very interesting for their potential use in medicine and biology.

• Periodical: Advanced Materials Research (Volumes 463-464)
• Pages: 538-542
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.463-464.538
• Online since: February 2012
• Authors: Jing Zhang, Li Yuan, Ya Dong Zhang
• Keywords: Fullerene-Amino Acid Conjugate, Synthesis

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