Antibacterial and Nontoxic Nano Silver PLLA Composites for Tissue Engineering

Abstract:

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Poly-L-Lactide (PLLA) composites were prepared with nano silver particles with the weight ratios of nano silver particles to PLLA (Ag/PLLA) at 0.5%, 2.5%, 5%, 7.5% and 10% (w/w). In vitro cytotoxicity tests were conducted firstly to evaluate the cytotoxicity of the composites. The results indicated that PLLA, 0.5%, 2.5% and 5% Ag/PLLA composites were nontoxic to cells, while 7.5% and 10% Ag/PLLA composites were significantly toxic to cells. Cell proliferation experiments and antibacterial tests were also performed. 5% Ag/PLLA was found the best for cell proliferation with obvious antibacterial property. Thus, Ag/PLLA can be used as nontoxic scaffolds for tissue engineering with antibacterial property.

Info:

Periodical:

Advanced Materials Research (Volumes 47-50)

Edited by:

Alan K.T. Lau, J. Lu, Vijay K. Varadan, F.K. Chang, J.P. Tu and P.M. Lam

Pages:

849-852

DOI:

10.4028/www.scientific.net/AMR.47-50.849

Citation:

L. Li et al., "Antibacterial and Nontoxic Nano Silver PLLA Composites for Tissue Engineering", Advanced Materials Research, Vols. 47-50, pp. 849-852, 2008

Online since:

June 2008

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Price:

$35.00

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