Antibacterial and Nontoxic Nano Silver PLLA Composites for Tissue Engineering

Lin Li; Yi Li; Jia Shen Li; Lei Yao; Arthur F.T. Mak; Frank Ko; Ling Qin

doi:10.4028/www.scientific.net/AMR.47-50.849

Paper Titles

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Dynamic Reinforced of Casting Alloys after Superdeep Penetration
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Fabrication of Poly(L-Latic Acid) Scaffolds with Wool Keratin for Osteoblast Cultivation
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Antibacterial and Nontoxic Nano Silver PLLA Composites for Tissue Engineering
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Microstructural Evolution during Warm Compression of Medium Carbon Steel Quenched
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Mass-Production of Practical Mussel Adhesive Protein in Escherichia Coli
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Smart Hybrid Mussel Adhesive Materials for Cell and Tissue Engineering
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Characterization of a Functionally Graded Hypereutectic Al-Si Alloy Produced by Centrifugal Method
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Antibacterial and Nontoxic Nano Silver PLLA Composites for Tissue Engineering

Abstract:

Poly-L-Lactide (PLLA) composites were prepared with nano silver particles with the weight ratios of nano silver particles to PLLA (Ag/PLLA) at 0.5%, 2.5%, 5%, 7.5% and 10% (w/w). In vitro cytotoxicity tests were conducted firstly to evaluate the cytotoxicity of the composites. The results indicated that PLLA, 0.5%, 2.5% and 5% Ag/PLLA composites were nontoxic to cells, while 7.5% and 10% Ag/PLLA composites were significantly toxic to cells. Cell proliferation experiments and antibacterial tests were also performed. 5% Ag/PLLA was found the best for cell proliferation with obvious antibacterial property. Thus, Ag/PLLA can be used as nontoxic scaffolds for tissue engineering with antibacterial property.