Synthesis and Characterization of a Biodegradable Poly (Glycerol-glycol-sebacate) Terpolymer

Abstract:

A biodegradable poly (glycerol-glycol-sebacate) terpolymer (PGGS) with different composition is prepared by a three-step method. The structure and properties of the PGGS terpolymers were characterized by means of attenuated total reflectance-Fourier transform infrared (ATR-FTIR), differential scanning calorimeter (DSC) and X-ray diffraction (XRD) methods. The experiment results indicate that the the composition of terpolymers have an obvious influence on the structure of PGGS terpolymers. The degradation rate increases with the increasing crosslink degree of PGGS.

• Periodical: Advanced Materials Research (Volumes 476-478)
• Pages: 2075-2078
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.476-478.2075
• Online since: February 2012
• Authors: Li Li Liu, Fa Cheng Yi, Wei Cai
• Keywords: Biodegradable, Biomaterial, Poly(glycol-Glycerol-Sebacate)

References

[1] Y. D. Wang, G. A. Ameer, B. J. Sheppard and R. Langer: Nat. Biotechnol. Vol. 20 (2002), p.602

[2] J. Bettinger, B. Orrick, Asish Misra, A. misra, R. Langer, J. T. Borenstein: Biomaterials Vol. 27(2006) , pp.2558-2565

DOI: 10.1016/j.biomaterials.2005.11.029

[3] Sundback, J. Y. Shyu, Y. D. Wang, W. C. Faquin, R. S. Langer, J. P. Vacanti, T. A. Hadlock: Biomaterials Vol. 26(2005), p.5454

DOI: 10.1016/j.biomaterials.2005.02.004

[4] F. Cicaoira, C. Santatao, M. Melucci, Laura Favaretto, Massimo Gazzano, M. MUccini, G. Barbarella: Adv. Mater. Vol. 18 (2006), p.165

[5] Y. D. Wang. Y. M. Kim, R. Langer: Biomed. Mater. Res. A 66A(2003), p.192

[6] K. Kim, S. Y. Lee and M. Xu: Polymer 37 (1996), p.5781

[7] Cai W, Liu LL: Mater. Lett. 62(2008), p.2171.

[8] B. K. Kim, S. Y. Lee and M. Xu: Polymer 37(1996) (26), p.5781

[9] K. Komatsu and M. Chiba: Arch. Oral Biol. 38(1993), p.369

[10] M. Chiba and K.Komatsu: J. biomech. 26(1993), p.561

[11] K. Misof, G. Rapp and P. Fratzl: Biophys. J. 72(1997), p.1376