Preparation of Arsenic Trioxide-Loaded PLGA Nanoparticles and Investigation of its Inhibitory Effects on Proliferation of Rabbit Vascular Smooth Muscle Cells In Vitro

Su Su Zhao; Qin Lu; Dong Sheng Zhang

doi:10.4028/www.scientific.net/AMR.60-61.125

Paper Titles

Effect of Ag Doping on Structural, Optical and Electrical Properties of SnS:Ag Thin Films Prepared by Pulse Electroposition
p.105

Characteristics of ZnMgO Thin Films Prepared by the Sol-Gel Method
p.110

Poly(4-vinylpyridine) Coated CdTe Core/Shell Quantum Dots
p.114

Analysis of Coupled Electro-Thermal-Mechanical of Micro Gas Pressure Sensor Based on Micro-Hotplate Technology
p.119

Preparation of Arsenic Trioxide-Loaded PLGA Nanoparticles and Investigation of its Inhibitory Effects on Proliferation of Rabbit Vascular Smooth Muscle Cells In Vitro
p.125

Experimental Studies of the Surface Forces on Micro Gap Plates with Different Bumps
p.130

Precision Calculation for Stiffness of the Complex Microstructure
p.135

Synthesis and Characterization of CdTe/PAA/P-4-VP Quantum Dots
p.141

Test on Sound Transmission Characteristic of PTFE Micro-Aperture Membrane
p.146

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 60-61Preparation of Arsenic Trioxide-Loaded PLGA...

Preparation of Arsenic Trioxide-Loaded PLGA Nanoparticles and Investigation of its Inhibitory Effects on Proliferation of Rabbit Vascular Smooth Muscle Cells In Vitro

Abstract:

Proliferation and migration of vascular smooth muscle cells(VSMCs) into the sub-intimal space play an important role in intimal thickening in atherosclerosis and in-stent restenosis. Arsenic compounds are natural substances that have been used in the treatment of patients with acute promyelocytic leukemia (APL).And Arsenic trioxide (As2O3) is known to be a potent inhibitor of cell proliferation.The aim of this study was to prepare arsenic trioxide (As2O3) -loaded PLGA nanoparticles(As2O3-PLGA-NP) and investigate its general properties, preservation of As2O3 bioactivity and their inhibitory effects on Rabbit Vascular Smooth Muscle Cells(RVSMCs) in vitro. With PLGA as carrier,As2O3 drug delivery nanoparticles were prepared by w /o /w double-emulsion evaporation technique，and their inhibitory effects on Rabbit Vascular Smooth Muscle Cells(VSMCs) in vitro was investigated.The results of the experiment show the self-prepared As2O3-PLGA-NP were approximately spherical,with the mean diameter of 90±25.03 nm, and the average drug loading was 1.72% .The As2O3-PLGA-NP has drug sustained-release character and can prolong the phase of the inhibitory effect of As2O3 against RVSMCs.The As2O3-PLGA-NP do not reduce the biological activity of As2O3.