Investigation on Temperature-Sensitive Poly (N-Vinylcaprolactam) Modified Calcium Alginate Microspheres

Abstract:

Temperature-sensitive calcium alginate-based microspheres were prepared in two steps. Firstly, free-radical polymerization of temperature-sensitive N-vinylcaprolactam monomer was performed in aqueous solution of sodium alginate, yielding a mixed aqueous solution bearing temperature-sensitivity composed of poly(N-vinylcaprolactam), sodium alginate-graft- poly(N-vinylcaprolactam) and sodium alginate. Then temperature-sensitive composite microspheres were prepared by inverse emulsification-crosslinking using the as-prepared solution as water phase, n-hexane as oil phase, Span-85 and Tween-85 as emulsifiers and calcium chloride as crosslinker respectively. The morphology and temperature-sensitivity of the composite microspheres were investigated by scanning electron microscope and turbidity method respectively. The controlled release behavior of the microspheres towards temperature was investigated preliminarily using berberine as a model drug.

• Periodical: Advanced Materials Research (Volumes 631-632)
• Pages: 145-149
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.631-632.145
• Online since: January 2013
• Authors: Wen Chao Wang, Xiao Mei Ma, Wei Huan Xu, Yin Yin Li, Quan Ji, Yan Zhi Xia
• Keywords: Alginate, Composite Microsphere, Controlled Release, Poly (N-Vinylcaprolactam), Temperature-Sensitive

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