Stability and Hopf Bifurcation for a HIV Infection Model with Delayed Immune Response

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In this paper, a class of HIV infection model with delayed immune response has been studied. We analyze the global asymptotic stability of the viral free equilibrium, and the stability and Hopf bifurcation of the infected equilibrium have been studied. Numerical simulations are carried out to explain the results of the analysis, and the change of the immune response of CTLs infects stability of system. These results can explain the complexity of the immune state of AIDs.

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Advanced Materials Research (Volumes 641-642)

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808-811

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January 2013

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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[1] C. Bartholdy, J.P. Christensen, D. Wodarz, A.R. Thomsen, Persistent virus infection despite chronic cytotoxic T-lymphocyte activation in Gamma interferon-deficient mice infection with lymphocytic choriomeningitis virus, J. Virol. 74 (2000).

DOI: 10.1128/jvi.74.22.10304-10311.2000

Google Scholar

[2] K. Wang, W. Wang, X. Liu, Global stability in a viral infection model with lytic and nonlytic immune response, J. Comput. Appl. Math. 51 (2007) 1593–1610.

DOI: 10.1016/j.camwa.2005.07.020

Google Scholar

[3] K. Wang, W. Wang, H. Pang, X. Liu, Complex dynamic behavior in a viral model with delayed immune response, Physica D 226 (2007) 197–208.

DOI: 10.1016/j.physd.2006.12.001

Google Scholar

[4] X. Song, S. Wang, X. Zhou, Stability and Hopf bifurcation for a viral infection model with delayed non-lytic immune response, J. Appl. Math. Comput. 33(2010) 251–265.

DOI: 10.1007/s12190-009-0285-y

Google Scholar

[5] Q. Xie, D. Huang, S. Zhang, J. Cao, Analysis of a viral infection model with delayed immune response, Appl. Math. Model. 34 (2010) 2388–2395.

DOI: 10.1016/j.apm.2009.11.005

Google Scholar

[6] X. Song, S. Wang, J. Dong, Stability properties and Hopf bifurcation of a delayed viral infection model with lytic immune response, J. Math. Anal. Appl. 373 (2011) 345–355.

DOI: 10.1016/j.jmaa.2010.04.010

Google Scholar

[7] X. Zhou, X. Song, X. Shi, Analysis of stability and Hopf bifurcation for an HIV infection model with time delay, Appl. Math. Comput. 199 (1) (2008) 23–38.

DOI: 10.1016/j.amc.2007.09.030

Google Scholar

[8] P.W. Nelson, A.S. Perelson, Mathematical analysis of a delay differential equation models of HIV-1 infection, Math. Biosci. 179 (2002) 73–94.

DOI: 10.1016/s0025-5564(02)00099-8

Google Scholar

[9] M. Chen and H. Zhu, Dynamics of a HIV infection model with delay in immune response, J. Biomath, vol. 24(4) , 2009, pp.624-634.

Google Scholar

[10] Hale J K. Theory of Functional Differential Equations[M]. New York: Springer-Verlag, (1997).

Google Scholar

[11] LaSalle J P. The stability of dynamical system[C]/ Regional Conference Series in Applied Mathematics. Philadelphia: SIMA, (1976).

Google Scholar

[12] E. Beretta and Y. Kuang, Geometric stability switch criteria in delay differential systems with delay dependent parameters,. SIAM J, Math Anal, vol. 33 , 2002, pp.1144-1165.

DOI: 10.1137/s0036141000376086

Google Scholar

[13] J. Li,Z. Ma, Stability switches in a class of characteristic equations with delay-dependent parameters, Nonlinear Analysis: Real World Applications, vol. 5 , 2004, pp.389-408.

DOI: 10.1016/j.nonrwa.2003.06.001

Google Scholar

[14] J. Hale and S.V. Lunel,. Introduction to Functional Differential Equations, Springer, New York , (1993).

Google Scholar