The Effects of Ligustrazine on the Expression of Bax Protein and Cytochrome C Following Focal Cerebral Ischemia/Reperfusion Injury in Rats

Abstract:

AIMS: To explore gene expressions of Bax and changes of cytC releasing in the CIR hippocampus neuron; to observe the effect on CIR with ligustrazine. METHODS: According to Bannisters, we made ischemia and reperfusion models of rat, and then using ligustrazine to cure; we observed the expression changes of Bax gene in hippocampus neurons by nucleic acid in situ hybridization, detecting cytC release through Western blotting. RESULTS: Ligustrazine protect neuron by reducing neuronal apoptosis induced by CIR, and inhibiting release of cytc by releasing.

• Periodical: Advanced Materials Research (Volumes 641-642)
• Pages: 824-827
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.641-642.824
• Online since: January 2013
• Authors: Qiu Zhen Zhao, Hua Liu, Hua Guang Li
• Keywords: CIR, Hippocampus, Hybridization In Situ, Ligustrazine

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