Effects of Four Mesostructures on their Drug Release Properties

Wei Zeng

doi:10.4028/www.scientific.net/AMR.645.125

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 645Effects of Four Mesostructures on their Drug...

Effects of Four Mesostructures on their Drug Release Properties

Abstract:

Five ordered mesoporous materials, SBA-1, MCM-48, SBA-7, MCM-41 and SBA-15, were prepared and tested as mesophase drug delivery systems with an anti-inflammatory drug, ibuprofen. The results of these mesostructures on in vitro ibuprofen delivery indicated that the mesoporous materials with cage-like structure, SBA-1 and SBA-7, had unfavorable load and release properties. MCM-48 also showed fast release rate due to its opening channel. However, the hexagonal mesostructure in MCM-41 and SAB-15 was advantageous for extending drug release rate although a little difference existed between them. Compared with commercial ibuprofen capsule, the release system based on MCM-41 materials displayed the drug efficacy in a longer time.

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Periodical:

Advanced Materials Research (Volume 645)

Pages:

125-128

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.645.125

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Online since:

January 2013

Authors:

Wei Zeng

Keywords:

Diffusion, Drug Delivery, Ibuprofen, Mesostructure, Sol-Gel (SG)

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