Biased AC Electroosmosis Device for the Detection of DNA Molecules with Piezoresistive Microcantilever

Md Shamsul Arefin

doi:10.4028/www.scientific.net/AMR.646.202

Paper Titles

A 8-Bit DAC Design in AMS 0.35 μm CMOS Process for High-Speed Communication Systems
p.178

A Comparison Study of Three of Input Buffer Designed Using 0.35µm CMOS Technology
p.184

Human Brain Phantom Modeling: Concentration and Temperature Effects on Relative Permittivity
p.191

A Novel Dual-Band Planar Wilkinson Power Divider
p.197

Biased AC Electroosmosis Device for the Detection of DNA Molecules with Piezoresistive Microcantilever
p.202

PD Control Law for Trajectory Tracking of Chaotic Pendulum
p.208

Performance Evaluation of 32-nm CNT-OPAMPs in Analog Circuits: Design and Comparison of Leapfrog Filters
p.216

Recent Research on the Magnetoimpedance Effect in Co-Based Amorphous Ribbons
p.222

Design and Performance Evaluation of a 10GHz 32nm-CNTFET IR-UWB Transmitter for Inter-Chip Wireless Communication
p.228

HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 646Biased AC Electroosmosis Device for the Detection...

Biased AC Electroosmosis Device for the Detection of DNA Molecules with Piezoresistive Microcantilever

Abstract:

This work represents active DNA concentration on piezoresistive microcantilever using biased AC electroosmosis. Two different sizes of DNA molecules, -phage DNA (48.5 kbp) and single-strand DNA of 20 nucleotides are concentrated on separate piezoresistive microcantilever sen- sor for detection. Before concentration, mixing of DNA molecules is performed using the same device for efficient concentration. During concentration of DNA molecules, biased and unbiased AC elec- troosmosis are needed to concentrate single-strand DNA and -phage DNA, respectively. Moreover, dielectrophoresis is induced by biased AC electroosmosis that can generate attractive force to trans- port negatively charged single-strand DNA. This paper represents a device configuration to integrate biased and unbiased AC electroosmosis and dielectrophoresis with piezoresistive microcantilever sen- sors for the detection of -phage DNA and single-strand DNA.