Facile Preparation of Polylactic Acid/Ketoconazole Composite Microspheres by Oil/Water Solvent Evaporation Method

Yan Hong Zhang; Yan Wang; Xian Chao Kong; Qian Ke Cheng; Xi Yuan Yang; Qing Wen Wang

doi:10.4028/www.scientific.net/AMR.652-654.335

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 652-654Facile Preparation of Polylactic Acid/Ketoconazole...

Facile Preparation of Polylactic Acid/Ketoconazole Composite Microspheres by Oil/Water Solvent Evaporation Method

Abstract:

In this study, polylactic acid(PLA)/ketoconazole(KCZ) composite microspheres were prepared by oil/water solvent evaporation method. Those drug-loaded microspheres were characterized in morphology using the scanning electron microscope (SEM). Fourier transform infrared spectroscopy (FT-IR) was used to determine the chemical functional groups in the sample and to analysis whether a chemical reaction occured between PLA and KCZ. The thermogravimetric spectra of PLA and PLA/KCZ microspheres were used to analyse the influence of KCZ on the thermal decomposition mechanism of PLA. Crystallinities of the KCZ and PLA/KCZ were analyzed by X-ray diffraction analysis (XRD).

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Advanced Materials Research (Volumes 652-654)

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335-338

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.652-654.335

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Online since:

January 2013

Authors:

Yan Hong Zhang, Yan Wang, Xian Chao Kong, Qian Ke Cheng, Xi Yuan Yang, Qing Wen Wang

Keywords:

Composite Microspheres, Ketoconazole, Oil/water Solvent Evaporation, Poly(lactic acid) (PLA)

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