Nanotoxicity of Magnesium Oxide on Human Neuroblastoma SH-SY5Y Cell Lines

N.I. Hasbullah; Mat Zain Mazatulikhma; N. Kamarulzaman

doi:10.4028/www.scientific.net/AMR.667.160

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 667Nanotoxicity of Magnesium Oxide on Human...

Nanotoxicity of Magnesium Oxide on Human Neuroblastoma SH-SY5Y Cell Lines

Abstract:

The use of magnesium oxide (MgO) nanoparticles in industrial applications has been raised over the last decade. However, there is limited toxicology information available regarding the effects of MgO nanoparticles. In this study, cytotoxicity and neurotoxicity of this nanoparticle on SH-SY5Y cell lines was investigated. In order to assess the cytotoxicity effect, SH-SY5Y cells were exposed to three different types of MgO nanoparticles (MgO 5, MgO 10 and MgO 24) for 24, 48 and 72 h. The concentration of nanoparticles ranges from 1nM to 1mM. Cell viability was determined by MTS assay. Neurotoxicity test was performed to determine the effects of MgO nanoparticles on human neural cells. Results indicated that MgO nanoparticles are not toxic to both undifferentiated and differentiated SH-SY5Y cells. With further exploration, the safety and health concern regarding exposure of MgO nanoparticles can be verified since the increasing of using this nanoparticle in industry over the time.

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Periodical:

Advanced Materials Research (Volume 667)

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160-164

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https://doi.org/10.4028/www.scientific.net/AMR.667.160

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Online since:

March 2013

Authors:

N.I. Hasbullah, Mat Zain Mazatulikhma, N. Kamarulzaman

Keywords:

Cytotoxicity, Magnesium Oxide Nanoparticles, Neurotoxicity, SH-SY5Y

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