Preparation and Characterization of Bio-Hydrogels for Biomedical Engineering

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In this work, a new crystalline PEO cross-linked CD films combining PEO and CDs (α-CD and β-CD) was prepared, and their compositions (CD/PEO; wt/wt) ranging from 1/99 to 6/94. The hydroxyl groups of PEO with Mn of 20,000 were converted to chlorine groups through reaction with thionyl chloride. PEO cross-linked CD films with various compositions were successfully prepared via the epoxy-amine reaction between amino-CD and PEO-epoxy. The thermal and swelling behavior were studied for the PEO cross-linked CD films. It was found that the cross-linked PEO films form hydrogel in water, achieving a swelling ratio higher than 20 times of original weight. The swelling properties of these cross-linked films depend on the fraction of CDs. The crystallinity of these films was very high, and crystallization rate of PEO was accelerated by cross-linking with CDs.

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276-279

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May 2013

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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