Synthesis, Characterization, and Drug Encapsulation of Hyperbranched Polyamidoamine Modified by β-Cyclodextrin

Xiao Long Jiang; Mi Zhou; Xiao Feng Ye; Xin Qian

doi:10.4028/www.scientific.net/AMR.718-720.267

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 718-720Synthesis, Characterization, and Drug...

Synthesis, Characterization, and Drug Encapsulation of Hyperbranched Polyamidoamine Modified by β-Cyclodextrin

Abstract:

h-PAMAM-COOMe and its β-CD derivatives (h-PAMAM-CD) were synthesized step by step via the Michael addition and ester-aminolysis reaction from hyperbranched polyamidoamine (h-PAMAM). The structures of the as-prepared polymers were confirmed by Ubbelohde viscometer, FTIR, and ¹H NMR. A series of inclusion complexation formed by β-naphtol in increasing h-PAMAM-β-CD with different concerntration were investigated by UV-vis spectrometer. The result showed that the novel hyperbranched polymer might have potential applications as delivery materials in chemotherapy.

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Advanced Materials Research (Volumes 718-720)

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267-270

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https://doi.org/10.4028/www.scientific.net/AMR.718-720.267

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July 2013

Authors:

Xiao Long Jiang, Mi Zhou, Xiao Feng Ye, Xin Qian

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Hyperbranched Polyamidoamine, Inclusion Complexation, β-Cyclodextrin

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