A Tunable pH-Responsive Nanomaterials for Cancer Delivery

Abstract:

In this paper, we successfully designed a pH-responsive micelles based on hybrid polypeptide copolymers of poly (L-lysine-4-Azepan-1-yl-butyric)-b-poly (ethylene glycol)-b-poly (L-lysine-Diisopropylamide)-b-poly (L-leucine) (PLL(A)-PEG-PLL(B)-PLLeu) for efficient drug delivery. This pH-responsive nanoparticles were able to response to different pH values (pH=6.8 and 5.5). In vitro, these nanoparticles exhibited a stable and evenly distributed approximately 51 nm, a slightly positive potential about 10.3 mv at pH 7.4, which were crucial for the circulation of drugs in blood. While size and potential were about 130 nm and 34.7 mv at pH 6.8, which were good for drugs in membrane. Furthermore, the loading capability of DOX was up to 11.3%, and the pH-responsive release efficiency reached to 68.3% at pH 5.5. The results indicated that these micelles had huge potential application in cancer delivery.

• Periodical: Advanced Materials Research (Volumes 750-752)
• Pages: 1476-1479
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.750-752.1476
• Online since: August 2013
• Authors: Bin Liu, Guan Hui Gao, Peng Liu, Hu Qiang Yi, Wei Wei, Zao Chun Ge, Lin Tao Cai
• Keywords: Cancer Delivery, pH-Responsive, Tunable

References

[1] E. Brewer, J. Coleman and A. Lowman, Journal of Nanomaterials, 2011, 2011, 1.

[2] J. -Z. Du, X. -J. Du, C. -Q. Mao and J. Wang, Journal of the American Chemical Society, 2011, 133, 17560-17563.

[3] I. Brigger, C. Dubernet and P. Couvreur, Advanced drug delivery reviews, 2012, 64, Supplement, 24-36.

DOI: 10.1016/j.addr.2012.09.006

[4] Y. Yan, G. K. Such, A. P. R. Johnston, J. P. Best and F. Caruso, ACS Nano, 2012, 6, 3663-3669.