Design and Electromagnetic FEM Analysis of a High Gradient Magnet for the Magnetic Targeted Drug Delivery System

Abstract:

Magnetic targeted-drug delivery system (MTDs) works as a promising cancer treatment approach, and is entering the mainstream. It applies an external magnetic field to attract and guide the magnetic nanoparticles (MNPs) carrying treatment agent and targeted antibodies to the lesion region. Its key factor is the high gradient magnet. Here three types of magnets are proposed, i.e., open circuit magnet, close circuit magnet with planar poles, and close circuit magnet with concave-convex poles. And then their magnet field distributions are calculated through the finite element method (FEM). The simulation results are compared with each other and the measurement of Gauss Meter for the manufactured magnet, and the primary experimental result is also reported. It is found the closed magnet circuit with concave-convex poles shows about 2.0 and 1.2 times higher magnetic field intensity (H) than the open magnet circuit and the close magnet circuit with planar poles, respectively. Most important is it owns largest Grad (H) (1.0 e6 A/m²) among three magnets. The simulation agrees well with the measurement, and the primary experimental results also show the magnet can attract MNPs efficiently. Hence the calculation enables provide with credible input for the further trajectory simulation for MNPs.

• Periodical: Advanced Materials Research (Volumes 753-755)
• Pages: 995-1001
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.753-755.995
• Online since: August 2013
• Authors: Rui Lin Zhang, Jie Feng, Ya Nan Qu, Ping Geng, Shou Liang Qi*
• Keywords: Finite Element Method (FEM), High-Gradient, Magnet Design, Magnetic Nanoparticles, Magnetic Targeted-Drug Delivery System

References

[1] Information on http: / www. who. org.

[2] M. Jain, G. Venkatraman, and S.K. Batra, Clin. Cancer Res., Vol. 13 (2007), p.1374.

[3] S.H. Jang, M.G. Wientjes, D. Lu, et al, Pharm. Res., Vol. 20 (2003), p.1337.

[4] K Cho, Xu Wang, S. Nie, et al, Clin. Cancer Rev., Vol. 14 (2008), p.1310.

[5] J. Vasir, V. Labhasertwar, Technol. Cancer Res. Treat., Vol. 4 (2005), p.363.

[6] C. Sun, J.S.H. Lee, and M.Q. Zhang, Adv. Drug Deliv. Rev., Vol. 60 (2008), p.1252.

[7] A.S. Lubbe, C. Bergemann, H. Riess, et al, Cancer Res., Vol. 56 (1996), p.4686.

[8] C. Alexiou, R. Jurgons, R. Schmid, et al, J. Magn. Magn. Mater., Vol. 293 (2005), p.389.

[9] M.A. Theresa, R.C. Pieter, Science, Vol. 303 (2004), p.1818.

[10] C. Alexiou, D. Diehl, P. Henninger, et al, IEEE Trans. Appl. Supercond., Vol. 6 (2006), p.1527.

[11] Q.L. Cao, X.T. Han, L. L, J. Magn. Magn. Mater., Vol. 323 (2011), p. (1919).

[12] A.E. David, A.J. Cole, B. Chertok, et al, J. Controlled Release, Vol. 152 (2011), p.67.

[13] H. Xu, T. Song, X. Bao, and L. Hu, J. Magn. Magn. Mater., Vol. 293 (2005), p.514.

[14] N.J. Darton, B. Hallmar, T. James, et al, J. Magn. Magn. Mater., Vol. 321, (2009), 321, p.1571.

[15] R. Asmatulu, M.A. Zalich, R.O. Claus, et al, J. Magn. Magn. Mater., Vol. 292 (2005), p.108.

[16] X.R. Wang, M. Tillack, and S.S. Harilal, in: 2-D magnetic circuit analysis for a permanent magnet used in laser ablation plume expansion experiments, University of California, San Diego, (2002).

[17] S.L. Qi, J.S. Zhang, J.H. Li, L. Ling, and J. Feng, in: In vitro experimental investigation on the key parameters for the embolism therapy using the magnetic nanoparticles, Proceedings of the 2010 3rd International Conference on Biomedical Engineering and Informatics (BMEI 2010), Vol. 4, 1511-1515.

DOI: 10.1109/bmei.2010.5639415

[18] Jie Feng, Ruilin Zhang, and Shouliang Qi, in: Design and Implementation of an Experimental Pulse Generator System, 2011 IEEE International conference on Intelligent Computation and Bio-Medical Instrumentation, 264-267.

DOI: 10.1109/icbmi.2011.54