Trajectory Simulation of Magnetic Nanoparticles in the Blood Vessel for the Magnetic Targeted-Drug Delivery

Abstract:

Magnetic nanoparticles (MNPs) have been considered as potential therapeutic agent carrier for the magnetic targeted-drug delivery in the fight against cancer. Trajectories of MNPs in the blood vessel determine the capture and retention ratio, and the final effectiveness of the treatment. In the present study, a theoretical model of MNPs trajectory is deduced at first. Then two kinds of magnets are proposed, and their magnetic field distributions are calculated through the finite element method software of ANSYS. Using the model and magnetic field inputs, the MNPs trajectories are determined, and the influences of the MNP diameter (R_p), the blood flow velocity (v_f) and magnetic field intensity (H) on the trajectories are clarified finally. It is found that the proposed method combining the theoretical model and numerical simulation is feasible. The closed magnetic circuit with concave-convex poles has better MNPs retention ratio than that of the open magnetic circuit because it has higher H and Grad (H). Large R_p, low v_f, and high H are good to capture the MNPs. Especially v_f and H are critical parameters for the retention ratio of MNPs, and high v_f and low H may let MNPs escape the magnetic field region.

• Periodical: Advanced Materials Research (Volumes 753-755)
• Pages: 988-994
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.753-755.988
• Online since: August 2013
• Authors: Jie Feng, Rui Lin Zhang, Ya Nan Qu, Ping Geng, Shou Liang Qi
• Keywords: Drug Delivery, Magnetic Nanoparticles, Magnetic Targeting, Trajectory Simulation

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