Inhibitory Effects of Natural Food Dyes Genistein on Invasion of SKOV3 Human Ovarian Carcinoma Cells In Vivo and In Vitro

Tang Li; Li Yu

doi:10.4028/www.scientific.net/AMR.781-784.1152

Paper Titles

Studies on the Chemical Constituents of Fritillaria monanth
p.1134

Researches on the Structure and Antioxidant Activity of Apigenin-La (III) Complex
p.1138

Effect of Plant Compound Curcumin on the Expression of SR-BI and ABCA1 in Hippocampal Neurons of APPswe/PS1dE9 Double Transgenic Mice
p.1144

Mechanisms of Natural Food Dyes Curcumin on Regulation of HO-1/HO-2 and Inhibition of Aβ-Heme Compound in Alzheimer's Disease
p.1148

Inhibitory Effects of Natural Food Dyes Genistein on Invasion of SKOV3 Human Ovarian Carcinoma Cells In Vivo and In Vitro
p.1152

The Effect of Plant Polyphenol Genistein on Migration of Endothelial Cells Induced by Human Ovarian Carcinoma Cell Line SKOV3
p.1156

The Regulation of Natural Food Dyes Curcumin on the Amyloidogenic Pathway of APP
p.1160

Progesterone Side-Chain Cleavage by Aspergillus versicolor
p.1164

Microbial Hydroxylation of Progesterone with Phomopsis Sp.
p.1168

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Inhibitory Effects of Natural Food Dyes Genistein on Invasion of SKOV3 Human Ovarian Carcinoma Cells In Vivo and In Vitro

Abstract:

The invasion behavior of tumor cells is important in the metastasis process of ovarian cancer cells. In this study we investigated the effects of Genistein on invasion inhibition in ovarian carcinoma cell line SKOV3 in vivo and in vitro. The abilities of the Genistein-treated SKOV3 cells to invade through reconstitute matrigel in transwell chambers were investigated in vitro and the invasion effect in vivo was determined by using the xenograft models of SKOV3 in nude mice. The ability of the 20μmol/L Genistein-treated cells to invade the reconstitute basement membrane was decreased significantly at 72h. This inhibition was dose-dependent. 40μmol/L Genistein had the strongest effect. The in vivo result suggested that the grade of invasion in control SKOV3 cells was time-dependent and Genistein-treated group could apparently inhibit the progress of invasion, localizing the tumor in invasion Grade 0 or Grade I and decreasing the proportion of Grade II, III and IV. The results suggested that Genistein possessed inhibitory effect on invasion in human ovarian carcinoma cell lines SKOV3 in vivo and in vitro.