The Regulation of Natural Food Dyes Curcumin on the Amyloidogenic Pathway of APP

Xiong Zhang; Jie Yun Sun; Hong Mei Zhang; Lu Si; Yu Li

doi:10.4028/www.scientific.net/AMR.781-784.1160

Paper Titles

Effect of Plant Compound Curcumin on the Expression of SR-BI and ABCA1 in Hippocampal Neurons of APPswe/PS1dE9 Double Transgenic Mice
p.1144

Mechanisms of Natural Food Dyes Curcumin on Regulation of HO-1/HO-2 and Inhibition of Aβ-Heme Compound in Alzheimer's Disease
p.1148

Inhibitory Effects of Natural Food Dyes Genistein on Invasion of SKOV3 Human Ovarian Carcinoma Cells In Vivo and In Vitro
p.1152

The Effect of Plant Polyphenol Genistein on Migration of Endothelial Cells Induced by Human Ovarian Carcinoma Cell Line SKOV3
p.1156

The Regulation of Natural Food Dyes Curcumin on the Amyloidogenic Pathway of APP
p.1160

Progesterone Side-Chain Cleavage by Aspergillus versicolor
p.1164

Microbial Hydroxylation of Progesterone with Phomopsis Sp.
p.1168

A Prophase Study on Applying Conia-Ene Reation in Constructing bicyclo [3, 3, 1] Nonane Ring
p.1172

Study on Synthesis of (S)-Methyl 2-(2, 2, 5, 5-Tetramethyl-1, 3-Dioxolan-4-Yl)Thiazole-4-Carboxylic Acid Methyl Ester
p.1175

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784The Regulation of Natural Food Dyes Curcumin on...

The Regulation of Natural Food Dyes Curcumin on the Amyloidogenic Pathway of APP

Abstract:

As a promising prevention and therapeutic intervention in Alzheimer’s disease, natural food dyes curcumin could obviously inhibit the generation of Aβ, but the mechanism is not fully defined. This study aims to investigate the effects of curcumin on the amyloidogenic pathway of APP in vitro. Plasmids APPswe and BACE1-mychis were transiently co-transfected into SH-SY5Y and HEK293 cells. Then, they were treated with curcumin at 0, 1.25, 5, 20 μmol/L for 24 h, or with curcumin at 5μmol/L for 0, 12, 24 and 48 h for the time course assay. Our findings showed that curcumin could inhibit the expression of the APP at mRNA level; the expression of the BACE1 and C99 at mRNA and protein levels, furthermore it could inhibit the generation of Aβ40/42, and those changes were dose-time dependent (p<0.05). Our study indicates that Aβ40/42 generation inhibition effect of curcumin might due to its influence on amyloidogenic pathway. This may provide important experimental basis for AD treatment with curcumin.

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Periodical:

Advanced Materials Research (Volumes 781-784)

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1160-1163

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https://doi.org/10.4028/www.scientific.net/AMR.781-784.1160

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September 2013

Authors:

Xiong Zhang, Jie Yun Sun, Hong Mei Zhang, Lu Si, Yu Li

Keywords:

Alzheimer's Disease, APP Processing, Aβ, BACE1, Curcumin

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