Study on Synthesis of (S)-Methyl 2-(2, 2, 5, 5-Tetramethyl-1, 3-Dioxolan-4-Yl)Thiazole-4-Carboxylic Acid Methyl Ester

Shi Peng Chen; Jian Ting Zhang; Dong Wang Liu; Lin Jun Tang; Jun Ming Feng; Xiao Ji Wang; Shuang Ping Huang

doi:10.4028/www.scientific.net/AMR.781-784.1175

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784Study on Synthesis of (S)-Methyl 2-(2, 2, 5,...

Study on Synthesis of (S)-Methyl 2-(2, 2, 5, 5-Tetramethyl-1, 3-Dioxolan-4-Yl)Thiazole-4-Carboxylic Acid Methyl Ester

Abstract:

(S)-methyl 2-(2, 2, 5, 5-tetramethyl-1, 3-dioxolan-4-yl) thiazole-4-carboxylic acid methyl ester, the unit containing thiazole of a cyclic depsipeptide Lyngbyabellin A which exhibited moderate cytotoxicity against KB and LoVo cells, was synthesized from methyl 3, 3-dimethylacrylate in overall yield 13.8% through nine steps, including asymmetric dihydroxylation, 2, 2-dimethoxypropane protection, saponification, coupling reaction, sulphonation, diazotization, cyclization, oxidation, and so on.

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Periodical:

Advanced Materials Research (Volumes 781-784)

Pages:

1175-1179

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.781-784.1175

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Online since:

September 2013

Authors:

Shi Peng Chen, Jian Ting Zhang, Dong Wang Liu, Lin Jun Tang, Jun Ming Feng, Xiao Ji Wang, Shuang Ping Huang*

Keywords:

3, 3-Dimethylacrylate, Lyngbyabellin A, Thiazole

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