Study on Synthesis of (R)-2,2-Dimethyl-3-(tert-butoxycarbonyl)-4-ethynylox-azolidine

Abstract:

(R)-2,2-Dimethyl-3-(tert-butoxycarbonyl)-4-ethynylox-azolidine, an intermediate of the natural product jaspine B, which was isolated from various sponges and endowed with cytotoxic activity against several human carcinoma cell lines, was synthesized from L-Serine in overall yield 43% through seven steps, including esterification, Boc protection, acetonization, reduction, Swern oxidation and Corey-Fuchs reaction.

• Periodical: Advanced Materials Research (Volumes 781-784)
• Pages: 1180-1183
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.781-784.1180
• Online since: September 2013
• Authors: Lin Jun Tang, Chang Shan Lv, Dong Wang Liu, Jun Min Feng, Shi Peng Chen, Jian Ting Zhang, Xiao Ji Wang, Shuang Ping Huang
• Keywords: (R)-2,2-Dimethyl-3-(tert-Butoxycarbonyl)-4-Ethynylox-Azolidine, Jaspine B, L-Serine, Synthesis

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