Microbial Hydroxylation of Progesterone with Phomopsis Sp.

Abstract:

Microbial hydroxylation of progesterone occurred in the biotransformation by Phomopsis sp.. The conversion products were purified by column chromatography with ether/EtOAc and characterized by spectroscopic methods including ¹HNMR, ¹³C NMR, IR, UV and MS. Those conversion products were identified as 11α-hydroxyprogesterone (2), 11α,15β-dihydroxy progesterone (3),11α-dihydroxypreg-1,4-dien-3,20-dione (4), 6β,15βdihydroxypregesterone (5) and 7β,15βdihydroxypregesterone (6).

• Periodical: Advanced Materials Research (Volumes 781-784)
• Pages: 1168-1171
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.781-784.1168
• Online since: September 2013
• Authors: Gang Du, Tian Chao Lai, Hai Ying Yang, Jing Xian Sun, Ming Hong Chen, Guang Qiu Zhang
• Keywords: Biotransformation, Hydroxylation, Phomopsis Sp, Progesterone

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