Synthesis and Characterization of Novel Roflumilast Analogues

Yu Hui Si; Gang Chun Sun; Ge Song; Wen Peng Mai; Zhi Cheng Li

doi:10.4028/www.scientific.net/AMR.781-784.1190

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784Synthesis and Characterization of Novel...

Synthesis and Characterization of Novel Roflumilast Analogues

Abstract:

A series of new roflumilast analogues with Crown ether structures were designed and synthesized. Crown-ether-type benzaldehydes were first prepared from 3,4-dihydroxybenzaldehyde with 1-bromo-3-chloropropane and 1-chloro-2-(2-chloroethoxy) ethane respectively, then after oxidation, acylation and amidation as the last step with 3,5-dichloropyridin-4-amine the roflumilast analogues were obtained. These compounds were characterised by ¹H NMR, IR, ESI-MS and elemental analysis.

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Periodical:

Advanced Materials Research (Volumes 781-784)

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1190-1193

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https://doi.org/10.4028/www.scientific.net/AMR.781-784.1190

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September 2013

Authors:

Yu Hui Si, Gang Chun Sun*, Ge Song, Wen Peng Mai, Zhi Cheng Li

Keywords:

Analogue, Crown Ether, Roflumilast, Synthesis

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