Wound Healing Based on PU/Hydrogel Nanocompounds Containing FGF-2 and Related Dressings by Radiation Method

Te Hsing Wu; Hong Ru Lin; Lie Hang Shen; Jia Hau Liu

doi:10.4028/www.scientific.net/AMR.79-82.437

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 79-82Wound Healing Based on PU/Hydrogel Nanocompounds...

Wound Healing Based on PU/Hydrogel Nanocompounds Containing FGF-2 and Related Dressings by Radiation Method

Abstract:

PU/hydrogel compounds prepared byγ-ray radiation technique were investigated in this study. We used nanosized clay solution or powder, Polyurethane (PU), thermosensitive N-isopropyl acrylamide (NIPAAm) and acrylic acid (AAc) as starting materials to prepare PU/hydrogel nanocomposite products. The dipping and weighing tests, Material Testing Machine (LLOYD) were utilized to analyze the physical and mechanical properties differentially. In addition, the drug release and wound closure experiments were also finished by Enzyme-link immunosorbent assay (ELISA) reader and five groups of treatment dressings. From the final results, We obtained that the PU/hydrogel composite incorporating FGF-2 as a wound dressing was able to effectively interact with the wound in a suitable moist healing environment. These composites make them more compatible with skin.

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Periodical:

Advanced Materials Research (Volumes 79-82)

Pages:

437-440

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.79-82.437

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Online since:

August 2009

Authors:

Te Hsing Wu, Hong Ru Lin, Lie Hang Shen, Jia Hau Liu

Keywords:

Fibroblast Growth Factor-2 (FGF-2), Hydrogel Composite, γ-Ray Radiation

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