Effect of Salidroside on Cardiac Functional Recovery

Yan Zhang; Zhong Hua Zheng; Yue Peng Wang; Guo Liang Peng; Liu Hang Wang

doi:10.4028/www.scientific.net/AMR.798-799.1030

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 798-799Effect of Salidroside on Cardiac Functional...

Effect of Salidroside on Cardiac Functional Recovery

Abstract:

To investigate the cardioprotective effect of salidroside to rat heart subjected to 8-hour hypothermic storage and 2-hour normothermic reperfusion. Isolated rat hearts were perfused with Langendorff model; after 30 minutes of baseline, the hearts were arrested and stored by St. Thomas solution (STS) without (STS group) or with different concentration salidroside at 4 °C for 8 hours, then reperfused for 2 hours. Compared with STS group, both middle and high dosage in STS greatly improved the recovery of left ventricular developed pressure (LVDP), maximum LVDP increase and decrease rate (±dp/dt), coronary flow rate (CF). Our study demonstrated that the salidroside was beneficial to improving cardiac functional recovery.

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Periodical:

Advanced Materials Research (Volumes 798-799)

Pages:

1030-1032

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.798-799.1030

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Online since:

September 2013

Authors:

Yan Zhang, Zhong Hua Zheng, Yue Peng Wang, Guo Liang Peng, Liu Hang Wang

Keywords:

Cardiac Function, Ischemia/Reperfusion Injury, Salidroside

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