A Novel Synthesis of AZT-5'-Glycosyl-1″-H-Phosphonate Diesters

Shan Shan Gong; Guo Dong Liu; Xing Jian Li; Qi Sun

doi:10.4028/www.scientific.net/AMR.830.159

Paper Titles

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A Novel H-Phosphonamidate method for the Synthesis of d4T 5′-Selenophosphoramidates
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A Practical Synthesis of 3β-Amino-5-Cholestene
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Microwave-Assisted FeCl₃·6H₂O-Catalyzed Regioselective Deprotection of Pyranose Anomeric O-Acetyl Group
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Dissolution of Absorbent Cotton in Ionic Liquid and Characterization of the Regenerated Cellulose
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 830A Novel Synthesis of...

A Novel Synthesis of AZT-5'-Glycosyl-1″-H-Phosphonate Diesters

Abstract:

A novel and efficient method for the preparation of O-AZT-5′- O-glycosyl-1-H-phosphonate diesters has been developed. The H-phosphonate diesters were synthesized by tandem substitution reaction on PCl₃ with 2,6-lutidine as base.

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Periodical:

Advanced Materials Research (Volume 830)

Pages:

159-162

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.830.159

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Online since:

October 2013

Authors:

Shan Shan Gong, Guo Dong Liu, Xing Jian Li, Qi Sun*

Keywords:

Antiviral Nucleoside, AZT, H-Phosphonate Diester, Prodrug, Tandem Substitution

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* - Corresponding Author

References

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